摘要
目的:建立酒精性骨质疏松症的动物模型,研究酒精对骨质疏松的影响。方法:SD大鼠分为3组:实验组A、实验组B及对照组。实验组A给予45°白酒8 ml.kg-1.d-1,每天2次灌胃,实验组B给予45°白酒6 ml.kg-1.d-1,每天2次灌胃,对照组以等量生理盐水灌胃,分别于8、16、24周后取材检测相关指标。结果:8周后实验组A尿液中尿吡啶酚(PYD)显著增高(P<0.01);16周后实验组A的BMD显著下降(P<0.01),各实验组的SOD活性较之同期对照组显著下降(P<0.05),MDA含量显著增高(P<0.05);24周后实验组A的TC、TG、LDL均显著增高(P<0.01),而HDL则显著降低(P<0.01)。结论:大量白酒灌胃,可致大鼠骨质疏松。
Objective： To produce animal model of alcoholic osteoporesis and to study the effect of alcohol on osteoporesis. Methods： Sprague-Dawley rats were randomly divided into three groups： test group A（Group A） ,test group B（Group B） and control group. 45° white wine was fed into stomachs of rats twice a day at doses of 8 ml· kg^-1· d^-1 and 6 ml· kg^-1· d^-1 in Group A and B respectivdy. In control group, the same dose of Sodium Chloride was fed. The specimens were obtained at 8th, 16th and 24th weeks after experiment to detect related indices. Results： At 8th week, the content of PYD in urine of Group A increased significantly （P 〈 0.01 ）. At 16th week, the content of BMD of Group A decreased significantly （P 〈 0.05）, and the SOD activity of two test groups decreased significantly as compared with control group （P 〈 0.05 ）, but the content of MDA increased （P〈 0.05 ）. At 24th week, the contents of TC, TG and LDL in the serum of Group A increased significantly （ P 〈 0.01 ）, but HDL content decreased significantly （ P 〈 0.01 ）. Conclusion： Drinking lots of white wine can induce osteoporesis of rats.
出处
《中国骨伤》
CAS
2005年第12期735-736,共2页
China Journal of Orthopaedics and Traumatology
基金
福建省教育厅科技项目(编号:JA03122)
关键词
酒精中毒
骨质疏松
动物
试验
Alcoholism
Osteoporosis
Animals,laboratory
