摘要
目的:应用Meta分析方法进一步了解帕罗西汀治疗脑卒中后抑郁的临床疗效和安全性。方法:实验于2005-08在暨南大学附属第一医院进行,应用计算机检索中国期刊网全文数据库(CNKI,1994/2005),主题词包括脑卒中后抑郁和帕罗西汀。文献纳入标准:论文内容包含有帕罗西汀治疗脑卒中后抑郁的对照研究;治疗效果以量表的量化性质反映出来,且为计量资料。应用Meta分析方法对检索出的符合要求的14项对照研究进行再分析,评价其综合显著性差异和效应大小。结果:①脑卒中后抑郁患者帕罗西汀治疗前后的汉密顿抑郁量表评分比较:综合检验Z=80.21,自由度28,P<0.0005;效应大小:d平均=4.96。②脑卒中后抑郁患者帕罗西汀治疗前后的神经功能缺损评分比较:综合检验Z=36.78,自由度18,P<0.0005;效应大小:d平均=2.56。③帕罗西汀治疗组与对照组抑郁症状改善程度的组间比较:综合检验Z=24.68,自由度28,P<0.0005;效应大小:d平均=1.82。④帕罗西汀治疗组与对照组神经功能改善程度的组间比较:综合检验Z=12.07,自由度18,P<0.0005;效应大小:d平均=0.95。⑤帕罗西汀治疗组与氟西汀对照组抑郁症状改善程度的组间比较:综合检验Z=0.23,自由度6,P>0.25;效应大小:d平均=0.17。结论:帕罗西汀对脑卒中后抑郁患者的抑郁症状和神经功能缺损有显著的改善作用,其副反应少,尤其适合于老年脑卒中后抑郁患者。
AIM： To further investigate the clinical effectiveness and safety of paroxetine in the treatment of post-stroke depression by using Meta analysis.
METHODS： The experiment was conducted in the Department of Emergency, the First Affiliated Hospital of Jinan University in August 2005. Using the keywords of ＂post-stroke depression, paroxetine＂, we searched the Chinese journals full-text database from 1994 to 2005. The inclusive criteria： randomized controlled trims about paroxetine in treating post-stroke depression; the results were reflected by the quantitative character of the scale and measurement data. Meta analysis was used to assess the comprehensively significant differences and effect size in 14 studies meeting the criteria.
RESULTS： ① Comparison of the scores of Hamilton depression scale （HAMD） in patients with post-stroke depression before and after treatment with paroxetine： comprehensive test Z=80.21, free degree 28, P〈0.000 5; effect size：dmean=4.96. ② The scores of CSS in patients with post-stroke depression before and after treatment with paroxetine： comprehensive test Z=36.78, free degree 18, P〈 0.000 5; effect size： dmean=2.56. ③ Improving degrees of depressive symptom between paroxetine treatment group and control group： comprehensive test Z=24.68, free degree 28, P 〈 0.000 5; effect size： dean=1.82.④ Improving degrees of neurological functional defect hetween paroxetine treatment group and control group： comprehensive test Z=12.07, free degree 18, P〈0.000 5; effect size： dmean=0.95.⑤ Improving degrees of depression symptom between paroxetine treatment group and fluoxetine control group： comprehensive test Z=0.23, free degree 6, P〈0.000 5; effect size： dmean=0.17.
CONCLUSION： Paroxetine can significantly ameliorate the depressive symptoms and neurological functional defects of patients with post-stroke depression. It has fewer side effects and especially fits senile cases of poststroke depression.
出处
《中国临床康复》
CAS
CSCD
北大核心
2005年第45期3-5,共3页
Chinese Journal of Clinical Rehabilitation
