摘要
目的研究婴幼儿肺炎并发不同程度心力衰竭时血清心肌肌钙蛋白I(cTnI)变化及其与心肌收缩、舒张功能的关系。方法选择133例肺炎及并发不同程度心力衰竭患儿作为实验组,健康婴幼儿30例作为对照组,均抽血测定血清cTnI,并应用多普勒超声心动图测定其左室射血分数(EF)、左室短轴缩短率(FS)及左房室瓣E峰与A峰比值(EV/AV)。结果各组间血清cTnI、EF、FS、EV/AV值有差异,心衰程度越重,血清cTnI越高,EF、FS、EV/AV越低,cTnI与EF、FS、EV/AV呈负相关。结论婴幼儿肺炎并发心力衰竭时,血清cTnI变化与心肌收缩功能及舒张功能呈负相关,cTnI参与心力衰竭的发生、发展,其变化可间接反映心脏收缩、舒张功能改变,指导临床诊断及治疗。
Objective To evaluate the relalionship between serum cTnI and systolic, diastolic function and discuss the role of cTnI and in the patients with infant pnemnonia eomplieated with CHF.Methods 133 patients with infant pneumonia and CIIF and 30 controls were studied. Serum eTnI and ejection fraction （EF）, fractional shortening （FS） and EV/AV by color Doppler ultrasonography were measured. Results Serum cTnI and EF, FS and EV/AV had the differees among five groups. With the disease deterioration, the values of eTnl increased and EF, FS, EV/AV decreased gradually. There were negative relation between cTnI and EF, FS, EV/AV. Conclusions There are negative relation between eTnl and systolic and diastolic function. This indicates eTnl takes part in the development of CHF. In clinical experimerltS, we can judge the cardiac systolic： and diastolic function by the levels of serum cTnI.
出处
《中国急救医学》
CAS
CSCD
北大核心
2006年第2期92-94,共3页
Chinese Journal of Critical Care Medicine
关键词
婴幼儿肺炎
充血性心力衰竭
心肌肌钙蛋白
心功能
Infant pneumonia
Congestive heart failure（CHF）
Cardiac troponin
Heart function
