摘要
采用双盲、随机交叉试验，观察了４７例ＮＩＤＤＭ患者口服碳酸锂或安慰剂治疗前后变化。结果表明：锂治疗后，①血糖、尿糖均降低（Ｐ＜０．０５或０．０１），降糖药与碳酸锂会用，降低愈加明显；②血浆胰岛素、Ｃ肽浓度均下降（Ｐ＜０．０５），胰升糖素无变化；③红细胞膜上胰岛素结合位点数增加（Ｐ＜０．０５），亲和力却降低（Ｐ＜０．０５）；④血Ｔ３、Ｔ４、皮质醇（Ｆ）等胰岛素拮抗激素浓度降低（Ｐ＜０．０１）。
Forty seven patients with non-insulin dependent diabetes mellitus given 0.2￣0.4 gram lithium carbonate per day or placebo accompanied with and without other conventional hypoglycemic agents by randomized, double-blind, cross-over design were studied. The changes of glucose metabolism, pancreatic A and B cell secretion, erythrocyte membrane insulin receptors were investigated. The results showed:①After lithium carbonate for 1 to 2 weeks, diabetic control of the patients improved significantly. On lithium carbonate combined with conventional hypoglycemic drugs, the blood and urine glucose concentrations decreased more markedly. These data suggest that lithium may have a hypoglycemic effect and the combined regimen can give better therapeutic effect.②After lithium treatment the concentrations of both plasma immune reactive insulin(IRI) and C peptide lowered but no change of glucagon. It suggests that lithium inhibits pancreatic B cell secretion,but has no effect on A cell secretion.③Under lithium therapy, the number of high-and low-affinity insulin receptors on erythrocyte membrane increased. We conclude that lithium may exert a hypoglycemic effect by increasing insulin receptor number and improving the sensitivity to insulin.④With lithium carbonate therapy, insulin-antagonist hormones like T3,T4, cortisol(F) decreased. These changes of hormones are probably involved in lithium's hypoglycemic effect. it suggests that lithium carbonate may inhibit thyroid function and then cause hypothyroidism in diabetics. Adrenal corticol secretion is also affected.
出处
《中国糖尿病杂志》
CAS
CSCD
1996年第3期151-154,共4页
Chinese Journal of Diabetes
基金
国家自然基金
关键词
碳酸锂
糖尿病
非胰岛素依赖型
药理学
Lithium carbonate
Glucose metabolism
Pancreatic function
