摘要
目的探讨慢性阻塞性肺疾病(COPD)稳定期患者血清α1-抗胰蛋白酶(α1-AT)质量浓度与气道炎症及肺功能的相关性。方法入选60例稳定期COPD患者及30例健康对照者,检测了入选对象的血清α1-AT、白介素-6(IL-6)、白介素-8(IL-8)、中性粒细胞弹性蛋白酶(NE)水平,并对60例COPD患者进行了肺功能检测。结果COPD患者血清α1-ATI、L-6I、L-8、NE水平均明显高于对照组,α1-AT质量浓度与NE水平正相关;COPD患者血清α1-AT质量浓度与肺功能残气量/肺总量(RV/TLC)明显负相关。结论稳定期COPD患者慢性气道炎症持续存在,血清α1-AT质量浓度与气道炎症程度正相关,与肺气肿程度负相关。
Objective To investigate the co-relations between serum α1-antitrypsin level and airway inflammation, and pulmonary function in stable COPD patients. Methods 60 stable COPD patients and 30 healthy controls were recruited, Their serums level of α1- antitrypsin, interleukin-6, interleukin-8 and neutrophil elastase, and the patients pulmonary function as well were detected. Results The findings show that the serum levels of α1-AT, IL-6,IL-8 and NE in COPD patients are much higher than those of the controls; there exist positive correlations between serum levels of α1-AT and NE and negative correlations between serum level of α1-AT and RV/YLC of pulmonary function, Conclusion This indicates that airway inflammation continues during the stationary phases in CDPD patients, that the serum α1-AT level are positive with the degree of airway inflammation, and negative with the degree of emphyscma.
出处
《首都医科大学学报》
CAS
2006年第1期35-37,共3页
Journal of Capital Medical University
