摘要
应用ＴＧＦ－β_１放免分析方法对１８例膀胱移行细胞癌进行研究，并选取９例正常膀胱为对照。结果显示：膀胱癌组织中ＴＧＦ－β_１蛋白表达量显著高于正常膀胱粘膜（Ｐ＜０．００１）。分期Ｔ_１组和Ｔ_２组ＴＧＦ－β_１蛋白表达量显著高于Ｔａ组（Ｐ＜０．０５和Ｐ≤０．００５）。Ｇ３组ＴＧＦ－β_１蛋白表达量显著高于Ｇ_１组（Ｐ≤０．０５）。应用￣３Ｈ－ＴｄＲ掺入实验研究表明：ＴＧＦ－β_１在体外可促进ＴＢＣ－１系膀胱癌细胞的体外生长。本组结果提示：ＴＧＦ－β_１蛋白的表达对膀胱癌的生物学行为有重要影响，对评估膀胱癌预后有重要意义。
TGF-β_1 was detected by radioimmunoassay in 18 bladder carcinoma and in 9 normal bladder mucosa as controls. The expression level of TGF-β1 was very significantly higher in bladder carcinoma than that in the normal bladder mucosa(P<0.001)and was significantly higher in T1 and T2 tumors than that in Ta tumors(P<0.05 and P≤0.005).The expression level was also significantly higher in grade 3 than in grade I tumors(P<0.05).With 3H-TdR incorporation assay,exogenous TGF-β1 was noted to stimulate the growth of TBC-1 bladder carcinoma cells in vitro. The results designated that TGF-β1 was relevant to the biological behavier of bladder carcinoma and might serve as an important marker for the evaluation of the prognosis of bladder carcinoma.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1996年第4期213-215,共3页
Chinese Journal of Urology
