摘要
目的 探讨中药肺痨宁对复治肺结核的免疫调节作用。方法 将67例复治菌阳浸润型肺结核病人随机分为治疗组（n=34）和临床对照组（n=33）。治疗组在常规抗结核治疗的同时加用肺痨宁，临床对照组只采用常规抗结核治疗，方案同治疗组。用酶联免疫吸附法（ELISA）检测两组治疗前及治疗1、3个月时病人血清中白细胞介素-12（IL-12）和γ-干扰素（IFN-γ）水平，同时以30例健康查体者作为正常对照组。结果 治疗前，治疗组与临床对照组的IFN-γ、IL-12值均低于正常对照组，差异有显著意义（F=13．962、5．275，q=2．898～6．975，P〈0．05、0．01）。治疗组治疗1、3个月后IFN-γ、IL-12水平均较治疗前升高，差异有显著性（t=2．403～9．575，P〈0．05、0．01）。临床对照组治疗3个月后IFN-γ、IL-12较治疗前升高，差异有显著性（t=3．396、2．951，P〈0．01）。与临床对照组比较，治疗组治疗1个月后IL-12水平升高，治疗3个月后IFN-γ水平升高，差异均有显著性（t=2．433、4．463，P〈0．01）。结论 中药肺痨宁可显著提高复治肺结核病人的细胞免疫功能。
Objective To assess the effects of Feilaoning on re-treated pulmonary tuberculosis. Methods Sixty seven patients with re-treated pulmonary tuberculosis were randomly divided into a trial group E34 cases, treated with 3Pa（H） L2VZ （TH） E（Ak） ＋ Feilaoning /6Pa（ H）L2V] and a control group [33 cases, treated with 3Pa（H） L2VZ（TH） E（Ak）/6Pa（H） L2V]. The levels of IL-12 and IFN-γ were detected with ELISA. Results The level of IL-12 was （37.27 ± 15.52） ng/L in the trial group after one month of therapy. There was significant difference between the two groups （F=13. 962,5. 275;q= 2. 898-6. 975; P〈0. 05,0.01）. The level of IFN-γ was （11. 209±3. 281 ）ng/L in the trial group after three months of treatment. A significant difference was noted between the two groups （t=3. 396,2. 951 ;P〈0.01）. Conclusion Feilaoning can improve the cellular immunity of the patients with re-treated pulmonary tuberculosis.
出处
《齐鲁医学杂志》
2006年第1期35-36,共2页
Medical Journal of Qilu
