摘要
目的研究核因子κB(NFκB)和表皮生长因子受体(EGFR)在胃癌及癌前病变中的表达和作用。方法应用免疫组化法检测NFκB与EGFR在35例正常胃黏膜、31例肠上皮化生、34例不典型增生与55例胃癌中的表达情况,并分析与胃癌临床病理之间的关系。结果NFκB阳性率在胃癌、不典型增生、肠上皮化生、正常胃黏膜中分别为78.2%、61.8%、58.1%、2.9%,在胃癌中高于肠上皮化生(P<0.05),EGFR阳性率在胃癌、不典型增生、肠上皮化生、正常黏膜中分别为83.6%、61.8%、80.6%、0%,在胃癌中高于不典型增生(P<0.05)。NFκB与EGFR阳性率在胃癌及癌前病变明显高于止常胃黏膜(P<0.01),低分化、浸润或淋巴结转移的胃癌中阳性率更高,并且在胃黏膜中表达存在等级相关性(r=0.588P<0.01)。结论NFκB与EGFR可能协同作用参与胃癌发生及进展,可以作为估计预后的指标。
Objective To investigate the expression and role of nuclear factor-κB（NF-κB） and epidermal growth factor receptor （EGFR） in gastric precancerous lesions and carcinoma. Methods Immunohistochemistry technology was used to detect the expression of NF-κB and EGFR in 35 cases of normal gastric mucosa, 31 cases of intestinal metaplasia, 34 cases of dysplasia and 55 cases of gastric carcinoma, and the correlations with the clinicopathological features of gastric carcinoma were analysed too. Results The positive rate of NF-κB in gastric carcinoma, dysplasia, intestinal metaplasia and normal mucosa were 78.2%, 61.8% ,58.1%, 2.9%, respectively, and the positive rate in gastric carcinoma was significantly higher than that in intestinal metaplasia（ P 〈 0.05）. The positive rate of EGFR in gastric carcinoma, dysplasia, intestinal me taplasia and normal mucosa were 83.6% ,61.8% ,80.6%, 0%, respectively, and there was significanty difference between carcinoma and dysplasia group（ P 〈 0.05）. The positive rate of NF - κB and EGFR in gastric precancerous lesions and carcinoma were significantly higher than that in normal mucosa （ P 〈 0.01 ）, Higher positive rate could be seen in gastric carcinoma with low differentiation, invasion or lymph node metastasis. There was correlation between the expression of NF-κB and EGFR（ r = 0.588 P 〈 0.01 ）. Conclusion NF-κB and EGFR may coact to induce the occurrence and progression of gastric carcinoma and act as prognosis indicators.
出处
《胃肠病学和肝病学杂志》
CAS
2006年第1期15-18,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
广东省科技计划项目(2003C30307)
关键词
核因子-ΚB
表皮生长因子受体
胃癌
癌前病变
Nuclear factor-κB
Epidermal growth factor receptor
Gastric carcinoma
Precancerous lesions
