摘要
目的探讨淋巴结内指突状树突细胞肉瘤的诊断要点及其鉴别诊断。方法对1例淋巴结内指突状树突细胞肉瘤进行组织病理学、免疫组化染色及电镜观察,并随访。结果患者临床表现为右颈部孤立性无痛性淋巴结肿大,易于复发。由于患者拒绝接受治疗,于确诊后15个月死亡。镜检显示淋巴结结构破坏,由呈束状、编织状排列的梭形和卵圆形细胞替代;瘤细胞vimentin、S_100(+),LCA、CD68灶性弱(+),CD21、CD35、CD1a及T、B细胞标记(-);电镜下瘤细胞表面可见细长的指状突起,未见到Birbeck颗粒、细胞间桥粒连接及黑素小体等特殊结构。结论指突状树突细胞肉瘤极为罕见,容易漏诊和误诊,熟悉其临床病理特点,依靠免疫组化和电镜可确诊。
Purpose To explore the clinienpathological features of interdigitating dendritic cell sarcoma （IDCS）in lymph node and its differential diagnosis. Methods A case of IDCS in left neck was analyzed by light microscopy, staining and electron microscopy. Results ＇lhe case presented a solitary painless mass in her right neck with local recurrence. ＇lhe patient refused to accept any treatment and died after 15 months. Microscopically, the lymph node structure was destroyed and substituted by spindle or oral cells arranged in whorls and a storiform growth pattern. Tumor cells were positive for S-100 and vimentin protein, weakly and locally positive for LCA and CD68, but negative for CD21, CD35, CDla and T or B cell markets. Ultrastructurally, the cell membrane showed slender, interdigitating processes and no special structures, such as Birbeck granules, desmesomes and melanesomes were noticed. Conclusions As a rare tumor, IDCS is often neglected or misdiagnosed. Immunohistochemistry and electron microscopy may contribute to the differential diagnosis of IDCS.
出处
《诊断病理学杂志》
CSCD
2006年第1期40-42,i0009,共4页
Chinese Journal of Diagnostic Pathology
关键词
指突状树突细胞肉瘤
淋巴结
免疫组化
电镜
Interdigitating dendritic cell sarcoma
Lymph node
Immunohistochemistry
Electron microscopy
