摘要
目的探讨非酒精性脂肪性肝病（NAFLD）对代谢异常及多元代谢紊乱发病的影响。方法从1995-2002年宝钢职工59131人次体检资料中，选取随访4-7年的NAFLD及其对照人群作为研究对象，应用SPSS11．5软件进行统计学处理。结果随访结束时，脂肪肝组肥胖症（76．6％对29．1％）、高血压（72．6％对51．2％）、高三酰甘油血症（52.6％对23．6％）、高总胆固醇血症（28.6％对20．4％）、空腹血糖受损（29．1％对14．8％）、糖尿病（17．1％对5．8％）以及多元代谢紊乱（50．3％对16．3％）的发病率均显著高于对照组。根据肥胖和脂肪肝的有无，将人选的862例研究对象重新分组，单纯脂肪肝组（69例）高血压（62．7％对41．1％）、高三酰甘油血症（38．1％对14．5％）、高总胆固醇血症（29．5％对16．3％）、空腹血糖受损（22．8％对9．6％）、糖尿病（10．8％对3．8％）和多元代谢紊乱（47．8％对11．3％）的发病率显著高于正常对照组（586例），与单纯肥胖组（101例）和脂肪肝＋肥胖组（106例）相近。脂肪肝对多元代谢紊乱的相对危险度（OR）为5．193。结论NAFLD促进高血压、高脂血症、空腹血糖受损、糖尿病以及多元代谢紊乱的发生，而且这种作用不依赖肥胖。
Objective To study the effects of nonalcoholic fatty liver disease （NAFLD） on the incidence of metabolic abnormalities and multiple metabolic disorders. Methods Patients with NAFLD and their age, sex, and occupation-paired control at least followed-up 4 years were chosen for research from 5,9131 person-time received periodic medical check-up biennially from 1995 to 2002, SPSS 11.5 of software was used for statistical. Results There were no difference of the ratio of men to women （ 156/19 vs 620/ 67） and mean follow-up （5.54 ± 0.94 vs 5.61 ± 1.00 years） between the fatty liver group （n = 175） and control group （n = 687）. The control group is older than the fatty liver group （40.56 ± 8.98 vs 38.83 ± 8.70 years）. At the end of follow-up, the incidence rates of obesity （ 76.6 % vs 29.1% ）, hypertension （72.6% vs 51.2% ）, hypertriglyceridemia （ 52.6 % vs23.6% ）, hypercholestemia （28.6% vs 20.4% ）, impaired fasting glucose （29.1% vs 14.8% ）, diabetes mellitus （ 17.1% vs 5.8% ） and multiple metabolic disorders （50.3% vs 16.3% ） in fatty liver group were significantly higher than those in control group. The overall 862 participants were regrouping according to obesity and （or） fatty liver at the based line, the incidence rates of hypertension （62.7% vs 41.1%）, hypertriglyceridemia （ 38.1% vs 14.5% ）, hypercholestemia （29.5% vs 16.3% ）, impaired fasting glucose （22.8% vs 9.6% ）, diabetes mellitus （ 10.8 % vs 3.8 % ） and multiple metabolic disorders （47.8 % vs 11.3 % ） in group of fatty liver alone （ n = 69） were significantly higher than the group of neither fatty liver nor obesity （n = 586）, but were not different from the group of obesity alone （n = 101 ） and the group of both fatty liver and obesity （n = 106）. The relative risk of fatty liver to multiple metabolic disorders is 5.193. Conclusion NAFLD might promote the development of hypertension, hyperlipidemia, impaired fasting glucose, diabetes mellitus and multiple metabolic disorders, independent of obesity.
出处
《肝脏》
2006年第1期7-11,共5页
Chinese Hepatology
