摘要
目的研究新生儿缺氧缺血性脑病(HIE)的血清褪黑素水平及其在不同病情和不同病期时的变化,阐明褪黑素在HIE发病与病情进展中的作用,并为褪黑素治疗HIE提供依据。方法用褪黑素放射免疫诊断试剂盒测定轻度和中重度HIE各20例急性期与恢复期的血清褪黑素值,并与20名正常足月新生儿作对照。分析HIE程度(轻度和中重度)、HIE病期(急性期和恢复期)对血清褪黑素水平的影响。结果(1)血清褪黑素水平在轻度HIE急性期时高于正常对照组,恢复期时与正常对照组无差异。(2)血清褪黑素水平在中重度HIE急性期时与正常对照组无差异,恢复期时高于正常对照组。(3)血清褪黑素水平在轻度HIE急性期高于恢复期,中重度HIE急性期低于恢复期。(4)血清褪黑素水平在HIE急性期轻度HIE高于中重度HIE,恢复期轻度HIE低于中重度HIE,差异均有显著性。结论褪黑素对HIE有一定的保护作用,病情较轻、急性期血清褪黑素水平升高的HIE预后较好,病情较重、急性期血清褪黑素水平降低的HIE预后较差。
Objective To elucidate the function of melatonin in the pathogenesis and the prognosis of hypoxic-ischemie encephalopathy （HIE） and provide the pathophysiology basis for theraping HIE with melatonin. Methods The level of plasma melatonin of twenty normal term infants and twenty modest HIE and twenty middle-severity HIE in their acute phase and recovery phase were assayed respectively with radioimmunoassay（RIA）. Then compare the difference of the melatonin level among these neonates. Results （1） For modest HIE, the melatonin level was higher than that in the normal in the acute phase and there was no difference to the normal in the recovery phase. （2） There was no difference between the melaton in level in middle-severity HIE in the acute phase and that in the normal, but in the recovery phase it was higher than that in the normal. （3） For modest HIE, the melatonin level in acute phase was higher than that in the recovery phase, but for middle-severity HIE, it was adverse. （4）In the acute phase, the level in modest HIE was higher than that in the middle-severity HIE, but on the contrary in the recovery phase. Conclusion Melatonin have protection action on HIE. The prognosis of modest HIE neonates with rising melatonin level in the acute phase is better than that with lower melatonin level of middle-severity HIE.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2006年第1期67-69,共3页
Suzhou University Journal of Medical Science
基金
苏州大学青年基金项目(Q3131029)
苏州市社会发展基金资助项目(ss0326)
关键词
褪黑素
缺氧缺血性脑病
新生儿
melatonin
hypoxic-ischemic encephalopathy
neonate
