摘要
目的探讨精神分裂症患者和正常人的项目记忆与源记忆的差异,检验项目记忆与源记忆有不同神经基础的假说,检验项目记忆与源记忆成绩和精神症状是否有关联性。方法采用对高频中文实义词的学习和再认的项目记忆任务与对同类物体的实义词、图片、想象三种表现方式的学习和再认的源记忆任务,对一般状况匹配的54例精神分裂症患者(研究组)和54名正常人(对照组)进行测试,比较两组项目记忆和源记忆成绩的差异,并对精神分裂症患者组进行双分离分析和阳性及阴性症状量表(PANSS)评分。结果研究组的项目记忆成绩Pr值和源记忆成绩I值分别为0.60±0.16和0.62±0.16,与对照组(分别为0.82±0.08和0.88±0.09)比较,差异均有显著性(P<0.001)。项目记忆成绩Pr值与精神症状不相关;而源记忆的成绩I值与PANSS总分、阳性症状评分之间存有相关性,分别为r=-0.283,P=0.038;r=-0.288,P=0.035。结论精神分裂症患者的项目记忆和源记忆均明显受损。有限的神经心理学研究分析显示,作为情景记忆的不同组成成分,项目记忆和源记忆的神经基础可能不同。
Objective To investigate the differences between schizophrenia patients and normal persons in the performances of item memory and source memory, to test whether source memory and item memory have different neural substrate, and to test whether the performances of item memory and source memory have correlation to the clinical symptoms in schizophrenia. Methods Fifty-four young persons and fifty-four schizophrenia patients were administered item memory task and source memory task. Item memory task includes the learning and recognition of high-frequency national Chinese characters ; source memory task includes the learning and recognition of three modes （ character, picture, and image） of objects. We compare the performances between two groups in these tests. Analysis within schizophrenia patients was performed to check the dissociation between item memory and source memory; The PANSS is employed for assessing the symptoms of schizophrenia patients. Results The performances of item memory （ Pr = 0. 60± 0. 16） and source memory （ I = 0. 62 ± 0. 16） in schizophrenia patients were significantly lower than that in young persons （0. 82± 0. 08, 0. 88 ±0.09. P 〈0. 001 ）. The performance of source memory （Ⅰ） had negative correlation to the global PANSS score and the global pesifive symptomatology score（ r =- 0. 283, P = 0. 038 ; r = - 0. 288, P = 0. 035, respectively ）, but the performance of item memory （Pr） had no correlation to anyone. Conclusions Item memory and source memory have impairment in schizophrenia patients. This study, from a limited neuropsychology prospective, indicates that item memory and source memory which are two different components in episodic memory may have different neural substrate.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2006年第2期97-100,共4页
Chinese Journal of Nervous and Mental Diseases
基金
国家自然科学基金(编号:30370479)
国家教育部归国留学人员科研启动资金(编号:[2003]14)
安徽省自然科学基金(编号:04043071)项目资助
关键词
精神分裂症
项目记忆
源记忆
症状
妄想
Schizophrenia Item memory Source memory Symptomatology Delusion
