摘要
以磷灰石-硅灰石玻璃陶瓷(AW)粉和β-磷酸三钙(β-TCP)粉为原料．以硬脂酸为致孔剂．经模压成型、1170℃烧结制备磷灰石-硅灰石／β-磷酸三钙复合多孔支架材料 (AW／β-TCP)．采用X射线衍射(XRD)、扫描电镜(SEM)、能谱(EDS)、诱导耦合等离子体原子发射光谱(ICP-AES)等方法分析支架的晶相组成、显微结构、物理性能、生物活性和降解性．将大鼠骨髓间充质干细胞(rMSCs)与支架体外复合培养评价支架的生物相容性．结果表明: 所制备的AW／β-TCP支架材料的抗压强度达14．3MPa．孔隙率达66．9％．孔径为100-700μm．具有良好的生物相容性、生物活性和降解性．可作为骨组织工程支架的候选材料．
Porous apatite-wollastonite/β-tricalcium phosphate composite scaffolds （AW/β-TCP） were prepared from apatite-wollastonite （AW） glass-ceramic powders and β-tricalcium phosphate （β-TCP） bioceramic powders, using stearic acid as porogen. The mixture powders were allowing compression molding and firing at 1170℃ to obtain porous composite scaffolds. Characteristics of the scaffolds were determined by X-ray diffraction （XRD）, scan electron microscope （SEM）, energy dispersive spectrum （EDS）, inductively couple plasma atomic emission spectroscopy （ICP-AES） and so on. Rat mesenchymal stem cells （rMSCs） were co-cultured with AW/β-TCP in vitro to evaluate the biocompatibility of the composite. Results show that： AW/β-TCP composite scaffolds with 30wt% of stearic acid reach the compressive strength of 14.3MPa, with the porosity as high as 66.9% and pore diameter ranging from 100 to 700μm. In vitro experiments reveal that AW/β- TCP scaffolds are biocompatible, bioactive and biodegradable. The porous AW/β-TCP composite is expected to be a candidate scaffold for bone tissue engineering.
出处
《无机材料学报》
SCIE
EI
CAS
CSCD
北大核心
2006年第2期427-432,共6页
Journal of Inorganic Materials
基金
国家863高技术计划(2002AA326080)教育部教学科研奖励基金(2002123)
