1Global Strategy for the Diagnosis,Management,and Prevention of Chronic Obstructive Pulmonary Disease.(Accessed August 9,2004 at:http://www.goldcopd.org).
2Pettersen CA,Adler KB.Airways inflammation and COPD:Epithelial-neutrophil interactions.Chest,2002,121 (5):S142-S150.
3M.acNee W.Oxidants/antioxidants and COPD.Chest,2000,117 (5 Suppl 1):S303-S317.
7Gomis-Ruth FX,Maskos K,Betz M,et al.Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.Nature,1997,389(6646):77-81.
8Hozumi A,Nishimura Y,Nishiuma T,et al.Induction of MMP-9 in normal human bronchial epithelial cells by TNF-a via NF-κB -mediated pathway.Am J Physiol Lung Cell Mol Physiol,2001,281(6):L1444-L1452.
9Zheng T,Zhu Z,Wang Z,et al.Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase and cathepsin dependent emphysema.J Clin Invest,2000,106(9):1081-1093.
10Pugin J,Widmer MC,Kossodo S,et al.Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators.Am J Respir Cell Mol Biol,1999,20(3):458-464.
