摘要
目的探讨健胃汤对溃疡愈合质量的影响及作用机制。方法采用大鼠乙酸胃溃疡模型,观察健胃汤对该模型溃疡愈合质量的影响,并用原位分子杂交法检测表皮生长因子受体mRNA(EGFRmRNA)的表达。结果健胃汤能改善胃黏膜组织损伤并提高溃疡周围组织EGFRmRNA的表达,与模型对照组比较,差异有显著意义(P<0.05)。结论健胃汤能提高溃疡愈合质量,增强溃疡瘢痕处EGFmRNA的表达可能是其作用机制之一。
Objective To investigate the the effect and mechanism of Jian-wei decoction（JWD） on quality of ulcer healing. Methods The rat models of chronic gastric ulcer were induced by acetic acid, the effects of QOUH of JWD on the model of gastric ulcer were observed, the expression of EGFRmRNA of mucosa were measured in situ hybridization. Results JWD could improve the injury of gastric mucosa and increase the expression of EGFRmRNA in the tissue around peptic ulcer（PU）. Conclusion JWD increases the expression of EGFRmRNA in the tissue around PU which might be one of possible mechanisms that JWD improves quality of ulcer healing.
出处
《中国基层医药》
CAS
2006年第2期187-189,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
胃溃疡
健胃汤
受体
表皮生长因子
疾病模型
动物
大鼠
Gastric ulcer
Jian-wei decoction
Receptor,epidermal growth factor
Disease models,animal
Rat
