摘要
目的:观察左卡尼汀和红细胞生成素治疗维持性血液透析患者肾性贫血的疗效,以及对红细胞生成素用量的影响。方法:将维持性血液透析肾性贫血患者40例随机分成两组,治疗组在应用红细胞生成素的同时口服补充左卡尼汀,对照组单用红细胞生成素,治疗8周,两组红细胞生成素初始用量均为每周150 U/Kg,当血红蛋白≥100 g/L,红细胞压积≥30%时,EPO逐渐减量至维持量。结果:两组患者的血红蛋白、红细胞压积较治疗前均有所提高(P<0.05),治疗组提高比对照组更显著(P<0.05),且治疗组红细胞生成素的维持用量更少(P<0.01)。结论:左卡尼汀能显著提高红细胞生成素治疗肾性贫血的疗效,减少红细胞生成素的用量。
Objective. To observe the effect of L-Carnitine and EPO in the treatment of patients with anemia of chronic renal disease in hemodialysis and the interaction with dosage of EPO. Methods：Forty patients with anemia of chronic renal disease in hemodialysis were randomly divided into 2 groups. L-Carnitine took orally with EPO given simultaneously in therapy group, and the control group given EPO only. All the patients were observed for 8 weeks. The initial dose of EPO in either of two groups was 150 U/kg weekly. The dosage reduced by degrees to maintenance dose when Hb≥100 g/L, Hct≥30%. Resultes：Both levels of Hb and Hct were improved （P〈0. 05）,but it was significantly higher in therapy group（P〈0. 05） ,and the maintenance dose in therapy group was less than that in contral group（P〈0.01）. Conclusion： L-Carnitine could significantly improve the effect of EPO in the treatment of the patients with anemia of chronic renal disease and reduce the dosage of EPO.
出处
《实用临床医学（江西）》
CAS
2006年第3期1-2,5,共3页
Practical Clinical Medicine
关键词
肾性贫血
左卡尼汀
红细胞生成素
anemia of chronic renal disease, L-Carnitine, erythropoietin
