摘要
目的探讨肿瘤坏死因子(TNF-α)及白细胞介素-6(IL-6)与肝硬化并发自发性细菌性腹膜炎(spontaneous bacterial peritonitis,SBP)的关系。方法用ELISA方法对32例肝硬化并发SBP和30例肝硬化漏出性腹水中TNF-α及IL-6进行检测,并作对照分析。结果肝硬化并发SBP组腹水TNF-α及IL-6明显高于肝硬化漏出性腹水组(P<0·01);SBP组病情重、死亡者腹水中TNF-α及IL-6质量浓度明显高于存活者;SBP组部分病例抗感染治疗临床表现有效后,腹水中TNF-α及IL-6质量浓度明显下降。结论检测腹水中TNF-α及IL-6水平可辅助诊断SBP,并可观察治疗效果、判断病情及预后。
Objective To investigate the clinical significance of tumor necrosis factor - α （ TNF - α） and intedeukin - 6 （IL- 6） in the ascitic fluid of cirrhotic patients with spontaneous bacterial peritonitis （SBP） . Methods TNF -α and IL - 6 in the ascitic fluid of 32 cirrhotic patients with SBP were measured by ELISA. The group was compared with the value in transudatory ascites of 30 cirrhotic patients. Results The levels of TNF - α and IL - 6 in the ascitic fluid of cirrhotic patients with SBP were much higher than those in transudatory ascites of cirrhotic patients （ P 〈0. 01 ） . In cirrhotic patients with SBP, the TNF-α and IL -6 levels in serious patients and deaths were much higher than living patients and markedly decreased in some patients after effective antibiotic treatmenL Condusion Our results suggest that the measurements of TNF - α and IL - 6 in ascitic fluid may be useful markers for the diagnosis of SBP, for monitoring the effect of treatment for cirrhotic patients with SBP and judging the prognosis.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2006年第2期206-207,共2页
Chinese Journal of Practical Internal Medicine
