摘要
目的探讨手术切除治疗喉癌的预后影响因素。方法收集1018例手术治疗喉癌患者的临床、随访资料,选择16个临床因素,通过单因素分析和Cox模型多因素分析,确定喉癌切除术后患者的预后影响因素。结果1018例患者3年生存率为79.1%,5年生存率为70.2%。术后各T、N分期患者5年生存率由高到低依次为T1N0、T1N+、T2N0、T3N0、T4N0、T2N+、T4N+、T3N+。单因素分析结果显示,年龄、声带活动度、术前T分期、术前阳性淋巴结、术前分期、术前分型、术后T分期、术后阳性淋巴结、术后分期、术后分型、肿瘤大小与手术治疗喉癌患者的预后有关(P<0.05)。Cox多因素分析结果显示,术后阳性淋巴结、声带活动度和肿瘤大小是手术治疗喉癌患者预后的独立影响因素。结论影响喉癌切除术后患者预后的独立因素是术后阳性淋巴结、声带活动度和肿瘤大小。坚持术后随访,及早发现肿瘤复发,及时行挽救性手术治疗是提高喉癌患者生存率的关键。
Objective To study the prognostic factors of 1018 patients with laryngeal cancer treated surgically. Methods All patients were treated surgically for laryngeal cancer from 1984 to 1996. A total of 16 clinical factors was studied by univariate analysis and Cox multivariate model. Results The follow-up rate was 93.5% over 5 years. The overall cumulative survival rate was 79.1% at 3 years, 70.2% at 5 years. The 5-year survival rate of T1N0 is the highest, followed by T1N＋ , T2N0, T3N0, T4N0, T2N ＋, T4N ＋ , and T3N ＋. In univariate analysis, the survival was related to patient age, mobility of vocal cords, preoperative T status, preoperative N status, preoperative UICC stage, postoperative T status, postoperative N status, postoperative UICC stage, topographic location of the tumor and tumor size. In Cox multivariate modal, only postoperative N status, mobility of vocal cords and tumor size were independent prognostic factors. Contclusion Independent prognostic factors for patients with laryngeal cancer after curative resection are postoperative N stage, mobility of vocal cords as well as tumor size. Postoperative follow-up and salvage surgery in time should be attached with importance to improve the survival of patients with laryngeal cancer.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2006年第3期211-213,共3页
Chinese Journal of Oncology
关键词
喉肿瘤
多因素分析
预后
Laryngeal neoplasm
Multivariate analysis
Prognosis
