摘要
目的：建立测定丽珠得乐中枸橼酸及其盐含量的光致变色法。方法：在pH1．8～2．2的酸性介质中，枸橼酸及其盐与Fe，＋生成的黄色配合物在日光照射下发生光致变色反应生成紫色配合物，光照时间为20min，冷水浴中静置25min,检测波长为490nm.结果：枸橼酸检测的线性范围为0～200mg／L，2个加入量的平均回收率分别为95．68％和95．94％（RSD分别为0．46％和0．21％），样品测定的精密度良好（RSD=0．63％）。结论：该法简便、灵敏、准确、专属性高、干扰少。
Objeelive： rio establish a method of photochromism for the quantitative determination of citrate in Bismuth Potassium Citrate tablets. Methods： In acid medium of pH 1.8 ～ 2.2, the yellow ferric （ Ⅲ） citrate complex changed into purple via photochromic reation. The illumination time was 20 min. The standing time in cold bath was 25 min. The detection wavelength was 490 nm. Results： The linear range of citrate was 0～200 mg/L. The average recoveries of two acceding quantities was 95.68% and 95.94% respectively （RSDs were 0.46% and 0.21% respectively）. The precision of sample determination was good （RSD was 0.63 % ）. Conclusion： The method is simple, sensitive, accurate, highly-specific and less interferential.
出处
《药学进展》
CAS
2006年第3期119-122,共4页
Progress in Pharmaceutical Sciences
关键词
光致变色
枸橼酸
含量测定
Photochromism
Citrate
Quantitative determination
