摘要
目的:在环丙沙星、氧氟沙星、左氧氟沙星、司帕沙星中寻找治疗复治耐多药肺结核病的最佳方案。方法:利用已有的文献资料,采用成本-效果分析方法进行评价;同时对可能的影响因素(价格)进行考察,并作敏感性分析。结果:在痰菌转阴率比较中,左氧氟沙星与司帕沙星效果相近,优于环丙沙星和氧氟沙星(P<0.05);空洞关闭率、X线病灶有效率、不良反应发生率等指标各组间比较无统计学意义(P>0．05)。各组间的医疗费用差异有统计学意义。结论:左氧氟沙星为最佳治疗方案。敏感性分析与成本-效果分析的结果一致。
Objective： To select a best therapeutic scheme for retreating multi-drug resistant pulmonary tuberculssosis among the four kinds of fluoroquinolones： Ciprofloxacin（ C）, Ofloxacin（ O）, Levofloxacin （V）, and Sparfloxacin （Sp）. Method： According to the principle of pharmacoeconomics, using cost-effectiveness analysis （ CEA）, the assessment and survey of the influencing factors （price） were carded out, and at the same time, a sensitive analysis was performed. Result： In the comparison of the sputum negative conversion rate, the bacteria rate of group O was similar to that of group C（ P 〉 0.05 ）. Group V resembled group Sp（ P 〉 0.05 ） ;Group V and group Sp dwarfed group C and group O respectively （ P 〉 0.05）. There was no statistical significance in the effect rates of X-ray examined focus or closure rates of cavities in the research groups （P 〉 0.05 ） ; There was no statistical significance in the rate of adverse reactions （ P 〉 0.05 ）. There were significant differences in cost among the four groups. Conclusion： Levofloxacin is the most effective and inexpensive scheme. The result of the sensitive analysis is in keeping with that of CEA, which indicates the credibility of CEA.
出处
《药物流行病学杂志》
CAS
2006年第2期99-101,共3页
Chinese Journal of Pharmacoepidemiology
关键词
喹诺酮类药
成本-效果分析
复治耐多药肺结核
左氧氟沙星
Fluoroquinones
Cost-effectiveness analysis
Retreating multi-drug resistant pulmonary tuberculosis
Levofloxacin
