摘要
目的探讨基质金属蛋白酶-9(MMP-9)在乳腺癌及癌旁正常组织中的表达及意义。方法应用免疫组化S-P法检测50例乳腺癌及癌旁正常组织中MMP-9的表达。结果在乳腺癌中MMP-9的表达明显高于癌旁正常组织(P<0.001),在有淋巴结转移组MMP-9的表达明显高于无淋巴结转移组(P<0.01)。结论MMP-9在乳腺癌组织中有高表达且在乳腺癌细胞突破基底膜向外扩散、转移中起着重要作用。
Objective To approach the expression of matrix metalloproteinase （MMP）-9 and its significance in breast carcinoma and corresponding non-tumor normal tissues. Methods The expression of MMP-9 was observed by S-P immunohistochemical technique in 50 cases with breast carcinomas and corresponding non-tumor normal tissues. Results The expression of MMP-9 in breast cancer was much higher than that in corresponding non-tumor normal tissues （P 〈 0.001 ）. Compared with breast carcinomas without positive metastasis, the expression of MMP-9 was up regulated in those with lymph node metastasis（ P 〈 0.01）.Conclusions MMP-9 may play an important role in the invasion and metastasis of breast cancer.
出处
《肿瘤基础与临床》
2006年第2期113-115,共3页
journal of basic and clinical oncology
基金
四川省宜宾市科技局重点科技项目(200403011)
关键词
乳腺癌
癌旁正常组织
基质金属蛋白酶
breast cancer
corresponding non-tumor normal tissues
matrix metalloproteinase
