摘要
目的探讨缬沙坦对原发性高血压(EH)病人血管内皮功能的影响。方法检测应用缬沙坦治疗前后EH病人血压、血管内皮素-1(ET-1)及一氧化氮(NO)的变化,并进行分析。结果应用缬沙坦后,EH病人血压显著下降(P<0.01)、ET-1明显降低(P<0.01),NO明显升高(P<0.01)。结论缬沙坦可有效降压,并能逆转EH病人血管内皮功能紊乱。
Objective To explore the effect of Valsartan on endothelial function in patients （pts） with essential hypertension （EH）.Methods Blood pressure, ET- 1 and NO value were determined and analyzed in 30 pts with EH pre - and post - therapy of Valsartan for 4 weeks. Results The plasma ET was higher in pts than that in the control group （P〈0.01） NO was lower in pts than that in the control group （P〈0.01）. Both of blood pressure and plasma ET were reducer greatly（ P〈 0.01 ）, while serum NO was increased significantly （P 〈 0.01 ） following Valsartan for 4 weeks. Conclusion Valsartan might be effective in the treatment of hypertension and might reverse the disturbance of impaired endothelial function in pts with EH.
出处
《中西医结合心脑血管病杂志》
2006年第4期302-303,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
高血压
内皮素
缬沙坦
hypertension
endothelial function
Valsartan
