摘要
目的:观察抗血栓药材醇提物的活血化瘀作用。方法:采用小鼠脑偏瘫、血小板聚集、毛细玻璃管法、高脂血症模型、急性血瘀证模型等试验方法,测定药物对小鼠脑血栓的保护率,血小板聚集的电阻率、凝血时间、血脂水平及对血液粘度的影响。结果:苦丁茶、山绿茶、绞股蓝、田七叶等对小鼠脑血栓模型有一定保护作用;苦丁茶、绞股蓝、田七叶等对血小板聚集有一定抑制作用;两面针、肉桂皮、绞股蓝、田七叶等具有抗凝作用;两面针、山绿茶、肉桂皮、山楂叶、绞股蓝、田七叶等具有降低血脂作用;两面针、山绿茶、山楂叶、绞股蓝等可改善急性“血瘀证”大鼠血液流变学指标。结论:本试验初筛结果为开发利用抗血栓药材提供了科学依据。
Objective ： to observe the effect of promoting blood flow to expel the blood stasis of antithrombotic medical material. Method： To adopt cerebral thrombosis of rat, platelet aggregation, glass capillary, the model of hyperlipemia, the model of acute stagnation of blood, and other experimental methods; To examine the protective rate of brain hemiparalysis of rat, resistivity of platelet aggregation, clotting time, blood fat level and the effect on blood viscosity. Result： these drugs, such as broadleaf holly leaf, Hainan holly leaf, gold theragran, radix notoginseng, et al, all had a certain protective effect on the model of cerebral thrombosis of rat; broadleaf holly leaf, gold theragran, radix notoginseng, et al, there were a certain depressant effect on platelet aggregation; Zanthoxylum nitidum DC, cassia, gold theragran, radix notaginseng, et al, there were the effect of anticoagulation; Zanthoxylum nitidum DC, hainan holly leaf, cassia, Chinese hawthorn leaf, gold theragran, radix notoginseng, et al; they could cut down the blood fat; Zanthoxylum nitidum DC, hainan holly leaf, Chinese hawthorn leaf, gold theragran, et al, these drugs could improve targets of haemorheology. Conclusion： the result of prdiminary screening supplied scientific basis for developing and utilizing antithrombotic medical material.
出处
《中医药导报》
2006年第4期1-3,6,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
国家科技部西部开发科技行动项目(编号:2002BA901A14)
广西科技厅科技攻关项目(编号:桂科攻0235022-1C)
关键词
抗血栓药材
筛选实验
Antithrombotic medical material
Screen assay
