摘要
目的研究妊娠相关血浆蛋白A(PAPP-A)在破裂斑块、不稳定斑块与稳定斑块中的表达、分布特点,探讨其在斑块破裂中的作用。方法对51例有明确冠心病病史的死亡病例分离冠状动脉组织并切片,从中选取破裂斑块、不稳定斑块(未破裂)和稳定斑块各15块,应用免疫组织化学方法进行PAPP-A染色。结果15块破裂斑块中有12例PAPP-A染色阳性,而所有不稳定斑块与稳定斑块PAPP-A染色均为阴性。结论PAPP-A与动脉粥样斑块的破裂密切相关,可能对急性冠状动脉综合征的诊断、危险分层及病情监测具有重要价值。
Objective To study the expression characteristics of pregnancy-associated plasma protein-A （PAPA-A）, as a serum inflammatory marker, in ruptured plaques, unstable plaques and stable plaques, in order to explore the role of PAPP-A in plaque rupture. Methods Coronary arteries were obtained at autopsy of 51 patients with defined coronary heart diseases. Sections of atherosclerotic plaques （ 15 each of ruptured plaques, unstable plaques and stable plaques） were made and examined by immunohistochemical staining method using monoclonal human antibody against PAPP-A. Results PAPP-A staining was positive in 12 of 15 ruptured plaques,and negative in all unstable and stable plaques. Conclusion PAPP-A is closely related with plaque rupture, and may be of great value in monitoring, diagnosis and risk stratification of acute coronary syndrome.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2006年第4期234-236,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
