摘要
目的:观察乌灵菌粉治疗青少年适应障碍的临床疗效和安全性。方法:选择2004-09/2005-06连续就诊于郑州大学第一附属医院心理门诊的青少年适应障碍的患者34例,均符合《中国精神疾病分类方案与诊断标准》第3版适应障碍诊断标准,进行为期6周的开放性乌灵胶囊治疗,其主要成分为乌灵菌干粉,是从珍烯药用真菌乌灵参中分离获得的菌种,经现代生物工程技术精制而成的纯中药制剂,服药方法为3粒/次,3次/d。以抑郁自评量表、焦虑自评量表和临床疗效总评量表为评估疗效的工具。结果:34例青少年适应障碍患者参加了实验,中途2例脱落,分别在治疗后2周、4周病情缓解而未复诊,其余32例患者完成了6周观察。①34例患者中有20例(59%)发病前存在2个或2个以上的应激事件,14例(41%)存在1个重要的生活变化事件。②32例患者完成6周研究,治疗结束时,抑郁自评量表、焦虑自评量表评分较治疗前明显下降(30.1±8.7,56.2±5.9;31.6±7.4,58.2±5.3),差异具有非常显著性意义(P<0.01)。③治疗后病情严重程度、疗效总评和疗效指数较治疗前明显下降(2.0±0.9,5.3±1.2;1.6±1.0,5.7±1.1;1.6±1.4,14.3±1.4),差异具有非常显著性意义(P<0.01)。④全部患者无明显副反应。结论:乌灵菌粉治疗青少年适应障碍安全、有效。
AIM： To investigate the clinical efficacy and reliability of wuling capsule on treating adjustment disorder of adolescents.
METHODS; Totally 34 adolescents with adjustment disorder were selected from Psychological Outpatient Clinic Affiliated to the First Hospital of Zhengzhou University from September 2004 to June 2005. All patients who met diagnostic criteria for adjustment disorder in Chinese Classification of Mental Disorders Ⅲ （CCMD-3） were treated with wuling capsule for 6 weeks, 3 pills/time, and 3 times/day. Wuling powder, the main component, was separated from wuling shen. and modified with modem biological engineering technique. Self-rating Depressive Scale （SDS）, Self-rating Anxiety Scale （SAS） and Clinical Global Impression （CGI） were used to assess clinical efficacy of wuling capsule.
RESULTS; Among 34 adolescents with adjustment disorder, 2 were lost in the mid-way and did not return visit 2 and 4 weeks after treatment because of remission, Other 32 patients received treatment within 6 weeks.① A- mong 34 cases, 20 patients （59%） attacked adjustment disorder with 2 or more stress events, and 14 cases （41%） with I important life event. ② Of 32 cases received treatment within 6 weeks, the scores of SDS and SAS were significantly decreased after treatment （30.1±8.7, 56.2±5.9; 31.6±7.4, 58.2± 5.3）, and there was a significant difference （P 〈 0.01）. ③ After treatment, severity of illness （SI）, global improvement （GI）and efficacy index （El） were significantly decreased as compared with those before treatment （2.0±0.9, 5.3±1.2; 1.6±1.0, 5.7±1.1; 1.6±1.4, 14.3±1.4）, and there was a significant difference （P 〈 0,01）. ④ There were no obvious side effects on all cases.
CONCLUSION： It is effective and safe for wuling capsule to treat adjustment disorder of adolescents.
出处
《中国临床康复》
CAS
CSCD
北大核心
2006年第15期45-47,共3页
Chinese Journal of Clinical Rehabilitation
