摘要
目的:从临床和基础两方面总结近年来中医药治疗慢性乙型肝炎肝纤维化的研究进展,分析目前仍存在的问题。资料来源:应用计算机检索中国期刊网全文数据库和中文科技期刊全文数据库2001-01/2005-11有关中医药治疗慢性乙型肝炎肝纤维化的文献,检索词“肝纤维化,乙型肝炎,慢性”,语言种类为中文。资料选择:对检索到的文献进行粗筛,选择与中医药治疗慢性乙型肝炎肝纤维化临床及实验研究相关的原著性文献,筛除明显非随机对照的文章,并对剩余文献查找全文,同时排除综述类文章和重复性研究。资料提炼:共检索到关于中医药治疗慢性乙型肝炎肝纤维化的文献90余篇,21篇文献符合纳入标准。资料综合:对收集到的资料进行汇总分析,从临床研究和实验研究两个方面,对近年来中医药治疗慢性乙型肝炎肝纤维化的文章进行概括和评价。临床研究主要从单味中药及有效提取物、中药复方、中成药、中西医结合、传统疗法等方面进行概括;实验研究则从四氯化碳致肝纤维化模型、二甲基亚硝胺致肝纤维化模型、免疫性损伤致肝纤维化模型、血吸虫肝纤维化模型四方面进行概括。结论:中医药防治肝纤维化近年来已取得了较大突破,但也存在着一些问题,需要继续不断深入和完善。今后应建立明确的疗效判定标准,尽量做到随机、双盲的开展临床研究,避免重复性研究;并需要加强乙型肝炎病毒复制模型的建立以缩短基础与临床的差距。
OBJECTIVE： To summarize the developing effect of Chinese herbs on treating hepatic fibrosis induced by chronic hepatitis B through clinical and basic researches and analyze some problems being still unclear.
DATA SOURCES： The relevant articles on treating hepatic fibrosis induced by chronic hepatitis B were retrieved from CNKI and VIP databases from January 2001 to November 2005 with the key words of ＂hepatic fibrosis, hepatitis B, chronic＂ in Chinese.
STUDY SELECTION： The data were screened glaneingly, and the original articles on treating hepatic fibrosis induced by chronic hepatitis B with Chinese herbs were selected. Some articles obviously lacking of randomized controlled trial were eliminated. The rest full texts were obtained, excluding reviews and repetitive researches.
DATA EXTRACTION： Totally more than 90 articles on treating hepatic fibrosis induced by chronic hepatitis B with Chinese herbs were collected. However, 21 literatures were coincidence with inclusion criteria.
DATA SYNTHESIS： The data of the selected articles were analyzed collectively. From the two aspects of clinical and experimental study, the studies on treating hepatic fibrosis induced by chronic hepatitis B with Chinese herbs were summarized and evaluated. Concretely, we summarized the clinical studies from the aspects Of single Chinese herbs, effective extract, the compound, the Chinese traditional patent medicine, the combination of Chinese traditional and Western medicine and the traditional therapeutics. The experimental studies were summarized from the four aspects of models induced by carbon tetrachloride, models induced by dimethyl-nitrosamine, models of immuno-damaged hepatic fibrosis and models induced by schistosomiasis.
CONCLUSION： The clinical and experimental study, which is on treating hepatic fibrosis induced by chronic hepatitis B with Chinese herbs, has procured some achievement. But it also exists some problems. Which should be developed further. For example, we should establish specific standard of curative effect, endeavor to carry out randomized controlled trials with double blind methods, avoid repetitive studies and study intensively how to induce the hepatic fibrosis model by hepatitis B virus in order to shorten the distances between the experimental and clinical study.
出处
《中国临床康复》
CSCD
北大核心
2006年第15期151-153,共3页
Chinese Journal of Clinical Rehabilitation
