摘要
目的:观察葛根素对非胰岛素依赖型糖尿病(2型DM)患者胰岛素抵抗(IR)及对血脂、纤溶活性异常的影响。方法:将80例存在IR的2型DM患者随机分为常规组(40例)及葛根素组(40例)。两组常规基础治疗相同;葛根素组加用葛根素注射液500mg静脉滴注,每日1次,3周为1个疗程。治疗前后检测两组血糖、血脂、胰岛素、纤溶指标。同时选择40名健康人作为对照组。结果:1与对照组比较,DM患者空腹血糖(FBG)、血浆胰岛素(FINS)浓度、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL C)增高,高密度脂蛋白胆固醇(HDL C)、胰岛素敏感指数(ISI)降低,纤溶酶原激活物抑制物1(PAI1)活性升高。FINS和ISI与血脂、纤溶指标存在高度线性相关。2葛根素组治疗后FINS、TC、TG、LDL C、PAI1均明显下降(P均<0.01),HDL C、ISI均明显增高(P均<0.01);FINS与TC、TG、IDL C、PAI1呈显著正相关,而与HDL C呈显著负相关;ISI与TC、TG、LDL C、PAl1呈显著负相关,与HDL C呈显著正相关。结论:葛根素能够改善2型DM患者的IR及与IR密切相关的血脂、纤溶功能异常。
Objective： To explore the effects of puerarin on insulin resistance （IR） and abormal lipid and fibrinolytic activity in patients with type 2 diabetes mellitus （DM）. Methods： Eighty patients with type 2 DM were divided randomly into two groups： 40 cases in the puerarin group and 40 cases in the routine treatment group. The conventional treatment of the two groups were the same. Additionally, patients in the puerarin group were given puerarin 500 mg in 250 ml of normal saline for intravenous dripping, once a day with a therapeutic course of 3 weeks. The changes of fast blood glucose （FBG）, lipid, insulin and plasminogen activator inhibitor - 1 （PAI 1 ） activity were measured before and after treatment,and the insulin sensitivity index （ISI） was calculated. Forty healthy subjects were taken as controls. Results： ①After 3 weeks of treatment, compared with the control group, in type 2 DM patients, FBG, fast insulin （FINS）, total cholesterol （TC）, triglyerides （TG）, low-density lipoprotein cholesterol （LDL -C） levels and PAI- 1 activity were higher, ISI and HDL -C were lower than those of the healthy controls. FINS and ISI were well correlated with lipid and fibrinolytie abnormality. ②After puerarin treatment, FINS, TC, TG, LDL C level, and PAI - 1 activity decreased and ISI, HDL -C increased significantly （all P-〈0.01） compared with the routine treated group. Correlation analysis showed that FINS was positively correlated with TC, TG, LDL C and PAI 1 and negatively correlated with HDL- C. ISI was negatively correlated with TC, TG, LDL C and PAI 1 and positively correlated with HDL C. Conclusion： Puerarin can improve the IR and abnormalities of IR related lipid and fibrinolytie activity in type 2 DM patients.
出处
《中国中西医结合急救杂志》
CAS
2006年第2期117-119,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
