摘要
目的:观察加味宣肺透解剂(JXT)对流感病毒感染小鼠细胞因子的影响。方法:复制流感病毒鼠肺适应株(FM1)小鼠肺炎模型,以加味宣肺透解剂灌胃治疗。ELISA法检测感染后第5天血清中IL-2、TNF-α、IL-6、IFN-γ的含量,肺组织切片HE染色。结果:加味宣肺透解剂明显升高血清中IL-2、IFN-γ水平,降低TNF-α、IL-6水平,减轻肺组织病变。结论:调节细胞因子的分泌,可能是加味宣肺透解剂减轻病毒感染小鼠肺组织损伤的机制之一。
Objective：To study the cytokine mechanism of Jiawei Xuanfei Toujie Ji（JXT） therapy to influenza infected mouse. Methods：Mice were inoculated intranasally with mouse lung-adapted influenza virus strain（FM1 ）, and were treated with JXT. At 5th days after postinoculation were sacrificed, and IL-2, TNF-α, IL-6, IFN-γin their sera were measured with ELISA kits, their lungs sections were stained with hematoxylin and eosin. Results：Compared with model group , the levels of IL-2 and IFN-γ in JXT group were dramatically higher, and the levels of TNF-α and IL-6 were lower, and pathological effects of influenza pneumonia showed less lung injury. Conclusion：Regulative effects on cytokine may be one of the factors that JXT decrease the pathogenesis of influenza-induced acute lung injury.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2006年第4期320-322,共3页
Chinese Journal of Immunology
