摘要
后发性白内障是现代白内障术后最常见的并发症。术后晶状体囊残留的晶状体上皮细胞的增殖、迁移、纤维化生是形成后发性白内障的主要原因。目前防治后发障的研究主要集中在药物除去或破坏残留晶状体上皮细胞。实验研究许多细胞毒药以及抑制晶状体上皮细胞生长和纤维化药物可以预防后发障,但目前临床上还没安全、有效的防治白内障方法。
The pathogenesis of posterior capsule opacification and the research on medical treatment posterior capsule opacification （PCO） is the most common complication following modern primary cataract surgery. PCO is caused by the lens epithelial cells retained in the capsular bag following surgery, which proliferate, migrate and transform to myofibroblasts. Current interest in the prevention of PCO has centred around pharmacological methods to remove or destroy lens epithelial cells. Many different cytotoxic drugs and pharmacological agents that inhibit lens epithelial cell and flbroblast proliferation have been used experimentally to prevent PCO. So far, no method has been shown to be safe for clinical use.
出处
《国际眼科杂志》
CAS
2006年第2期412-416,共5页
International Eye Science
关键词
后发性白内障
机制
药物治疗
posterior capsule opacification
mechanism
medication
