摘要
目的:肝脏管道灌注后进行数字化虚拟肝脏及其手术的研究.方法:用四种颜色的灌注材料对肝脏的四种管道分别进行灌注和固定,然后进行包埋、冰冻和铣切,获取连续肝脏断面图像数据集.再将数据集的图像经配准和分割后在VTK的基础上,使用面绘制和体绘制相结合的方法,进行三维重建和虚拟切割实验.结果:获取肝脏连续肝脏断面图像910张,且四种管道颜色不同.三维重建肝脏模型形态逼真,能随意旋转、放大和缩小,通过设定肝脏及其各管道结构的透明度和颜色能单独或组合显示各结构.并且在模型上能行虚拟肝脏切割实验.结论:不同颜色灌注材料对肝脏管道灌注后铣切获取连续断面数据集有益于肝实质及其内部各管道的识别.以此进行三维重建和虚拟手术的研究,有益于肝脏解剖学和肝脏外科的研究.
AIM： To study the digitized virtual liver and hepatic surgery after filling hepatic duct systems. METHODS： Four kinds of intrahepatic ducts were perfused with different filling material ex vivo respectively. And then the samples were used to be frozen, embedded and sliced to obtain serial sectional images. The whole series of hepatic images was employed to reconstruct a 3 dimensional （3D） liver. After the image registration of the tis- sue sections, the image information of liver parenchyma, hepatic veins, bile duct and cholecyst was obtained by image segmentation, followed by the 3D reconstruction using Visualization ToolKit （VTK） to construct a 3D morphological model of the liver surface and intrahepatic structures. The virtual liver could also be resec- ted at any angle to observe the structure of the resection surface. Furthermore, a Windows PC-based 3D visualized demonstration system and Windows operation system of liver were developed. RESULTS： Total 910 consecutive sectional images of liver were taken. Hepatic arteries, inferior cava veins/hepatic veins, portal veins and biliary ducts were shown with red, blue, green, and yellow colors, respectively. This demostration system of liver pro- vided a graphic user interface to rotate and scale the 3D liver to observe 3D morphological features of the liver and its duct systems by setting the pellucidit and color. A virtual liver simulation system for resection with primary function was established. CONCLUSION ： The technique of perfusion of hepatic ducts may be beneficial to identification of intrahepatic structure. And research on digitized virtual liver and virtual hepatic surgery may be beneficial to the development of the hepatic anatomy and surgery.
出处
《第四军医大学学报》
北大核心
2006年第8期712-716,共5页
Journal of the Fourth Military Medical University
基金
国家自然科学基金(30470493)
广东省科技计划项目(2003C34303)
关键词
肝
图像处理
计算机辅助
三维重建
虚拟手术
liver
image processing, computer-assisted
threedimensional reconstruction
virtual surgery
