摘要
日本学者报告Vaspin是一种新识别出来的脂肪细胞因子，是由内脏脂肪组织产生的丝氨酸蛋白酶，2型糖尿病模型的大鼠它被上调，而非肥胖和耐糖尿病大鼠，它被下调。
There is a rapid global rise in obesity, and the link between obesity and diabetes remains somewhat obscure. We identified an adipocytokine, designated as visceral adipose tissue-derived serpin （vaspin）, which is a member of serine protease inhibitor family. Vaspin cDNA was isolated by from visceral white adipose tissues （WATs） of Otsuka Long-Evans Tokushima fatty （OLETF） rat, an animal model of abdominal obesity with type 2 diabetes. Rat, mouse, and human vaspins are made up of 392, 394, and 395 amino acids, respectively; exhibit 40% homology with 1-antitrypsin; and are related to serine protease inhibitor family. Vaspin was barely detectable in rats at 6 wk and was highly expressed in adipocytes of visceral WATs at 30 wk, the age when obesity, body weight, and insulin levels peak in OLETF rats.
出处
《中国分子心脏病学杂志》
CAS
2005年第5期752-752,共1页
Molecular Cardiology of China
