摘要
目的探讨子宫内膜癌中P27蛋白的表达及其临床意义。方法采用免疫组化SP法检测42例子宫内膜癌中P27蛋白的表达,并与正常子宫内膜和增生内膜进行了对比。结果子宫内膜癌中P27蛋白胞核高表达率为21.4%,明显低于正常子宫内膜和增生子宫内膜,差异有显著性(2χ=5.470、12.306,P<0.05);P27蛋白胞核表达与组织学分级有关,分化差者P27蛋白胞核表达率低(2χ=12.715,P<0.01);内膜癌中P27蛋白胞浆表达阳性率为47.6%,明显高于正常子宫内膜和增生内膜(H=57.656,P<0.01)。结论P27蛋白胞核表达缺失与子宫内膜癌的发生发展及恶性程度的增高有关;P27蛋白胞核定位缺失与其功能丧失有关。
Objective To investigate the expression of P27 protein in endometrial carcinoma and its clinical significance. Methods The expression of p27 protein was detected in 42 cases of endometrial carcinoma with immunohistochemical technique, and compared with that in normal endometrlum and hyperplastic endometrium. Results The high nuclear expression rate of P27 protein in endometrial carcinoma was 21.4%, significantly lower than that in the normal endometrium and hyperplastlc endometrium（X^2 =5. 470,12. 306 ; P〈0. 05）. Nuclear expression of P27 protein was related with cell differentiation and it was low in moderately and poorly differentiated cells（X^2=12. 715 ,P〈0.01）. The cytoplasmic stain of P27 in endometrial tumor cells was 47.60%, which was significantly higher than that in normal endometrium and hyperplasia endometrium（H =57. 656 ,P〈0.01）. Conclusion The deletion of nuclear expression of P27 is related to the genesis and development of endometrial cancer and its increased malignancy. The loss of nuclear localization of P27 protein is associated with inactivity of the protein.
出处
《青岛大学医学院学报》
CAS
2006年第2期147-149,共3页
Acta Academiae Medicinae Qingdao Universitatis
