摘要
目的：探讨保留卵巢功能对宫颈癌患者放射治疗后内分泌及生活质量的影响.方法：1995年6月～2001年6月对年龄35岁下,临床Ⅰ、Ⅱ期的宫颈癌患者64例随机分成两组：实验组（卵巢移位＋放疗）32例,先行手术将卵巢保留并移位至照射区外5cm处,然后行盆腔根治性放疗;对照组（单纯放疗）32例,直接行盆腔根治性放疗.观察两组放疗后性激素水平变化及临床表现,并进行对照分析.结果：实验组放疗后血清FSH、LH、E2、T值较放疗前无显著变化（t=0.72,P＞0.05）,阴道细胞学检查有雌激素影响.B超示卵巢有周期性增大改变,临床表现无怕热、心烦、多汗、肥胖、皮肤粗糙等内分泌失调症状.对照组放疗后FSH、LH值显著增高（t=15.53,P＜0.01）,E2值都显著降低（t=6.61,P＜0.01）,阴道细胞学检查无雌激素影响.B超示卵巢无周期性变化,临床表现有怕热、多汗、烦躁、皮肤粗糙等内分泌失调症状.与实验组比较（χ^2=32.0,P＜0.01）,结果证明卵巢移位后能避免卵巢功能丧失.结论：保留卵巢功能可以提高年轻宫颈癌患者放射治疗后的生活质量.
Objective： To study the effect of ovary function preservation on endocrine and life quality for the young patients with cervix carcinoma. Methods： From June 1995 to June 2001,64 young patients with cervix carcinoma in stage Ⅰ , Ⅱ were randomly divided into two groups. 32 cases served as study group（ ovarian transposition ＋ radiotherapy） underwent ovary transposition by surgery and subsequent irradiation of pelvic part, 32 cases served as control group（ conventional radiotherapy） underwent radiotherapy, The sex hormone level and clinical situation were compared. Results： For study group, the serum FSH, LH, E2 , T values had no notable changes after radiotherapy （ t = 0. 72, P 〉 0.05 ）. Colpo-cytoscoph had estrogen effect. Ultrasonography proved that ovaries had periodical augment. No patients had endocrine disorders such as fear of heat, upset, hidrosis, obesity, skin roughness. In contrast, for control group, FSH and LH values increased strikingly （ t = 15.53, P 〈 0.01 ） , while E2 value decreased notably （ t = 6. 61, P 〈 0. 01 ）. All patients had endocrine disorders （χ^2 =32. 0,P 〈0. 01 ）. This illlustrated the loss of ovary function. Conclusion：h is necessary and important to preserve the ovary function for young patients in radiotherapy.
出处
《临床肿瘤学杂志》
CAS
2006年第4期274-276,共3页
Chinese Clinical Oncology
关键词
宫颈癌/放射疗法
卵巢移位
性激素
Cervix carcinoma/radiotherapy
Ovary transposition
Sex hormone
