摘要
目的了解使用过氧乙酸进行空气消毒对暴露人群健康产生的不良影响。方法2004年12月,选择29名志愿者,选择2间教室,按照卫生部《传染性非典型肺炎医院感染控制指导原则(试行)》喷洒过氧乙酸(2%)进行室内空气消毒(共3d,消毒6次),0.5h后,受试者进入教室并停留3h,分别在消毒前1d、接触过氧乙酸1、2d和脱离接触1周后检测受试者血常规、肝功能、肾功能、血中免疫球蛋白E(IgE)和组胺含量等,并于接触消毒剂2d后填写不良反应问卷调查表。结果受试者接触消毒剂后,主观均感到不同程度的不适;与接触前比较,接触过氧乙酸2d、脱离接触过氧乙酸1周后受试者白细胞均升高(P<0.01),接触过氧乙酸后1、2d、脱离接触过氧乙酸1周后受试者单核细胞均升高(P<0.01),脱离接触1周后受试者白细胞又比接触过氧乙酸后2d下降。肝功能、肾功能、免疫球蛋白E(IgE)、组胺等指标则没有明显变化。结论按照卫生部的医院感染控制指导原则使用过氧乙酸进行空气消毒,暴露人群可能会出现多种主观不适,白细胞和单核细胞计数升高,但脱离接触1周之后,除单核细胞之外,其他所有指标都恢复至暴露前水平,说明这种损伤是可逆的。
Objective To evaluate the potential adverse effects of peracetic acid on exposed people when it was largely used as an air disinfectant in the public area. Methods 29 volunteers （14 males, 15 females） were enrolled to take part in the experiment. The indoor areas were disinfected with peracetic acid according to the Guideline to Control the Hospital Infection During the SARS Period issued by the Ministry of Health. 4 ml blood were collected from the volunteers to determine the blood routine indexes, liver function, kidney function and histamine before peracetic acid exposure, after 1-2 days of the exposure and one week after exposure. A questionnaire about the subjective adverse effects was required to be filled in after exposures. Results All the volunteers felt, to different extent, uncomfortable after exposed the disinfected air, the white blood cells and monocytes increased （P〈0.05）, that demonstrated a potential inflammation. One week after the exposure, all the changed indexes recovered to the levels before exposure except the monocytes. Conclusion If the indoor disinfection with peracetic acid is conducted according to that established guideline, some uncomfortable symptoms and decrease of monocytes and WBC will occurs, one week after exposed, however, all the changed indexes will recover except the monocytes, that means such impairments are reversible.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2006年第3期228-230,共3页
Journal of Environment and Health
基金
科技部SARS科技专项课题(2003A07)
关键词
空气污染
室内
消毒
过氧乙酸
Ⅰ型过敏反应
肝功能
肾功能
Air pollution, indoor
Disinfection
Peracetic acid
I type hypersensitivity
Liver function
Kidney function
