摘要
目的:比较天舒胶囊(川芎、天麻等)和氟桂利嗪对偏头痛的疗效。方法:82例偏头痛患者随机分为治疗组(40例)和对照组(42例)。治疗组给予天舒胶囊,每天3次,每次4粒(共1.36 g),饭后口服,连用2个月,对照组给予氟桂利嗪胶囊每晚1粒(5 mg)。治疗2个月。患者在观察期间不得服其它镇痛剂。记录偏头痛发作频率和每月头痛发作持续时间,停药后仍具有阳性结果的持续时间,出现副作用的时间。治疗前及治疗2个月时进行体重以及血、尿常规,肝、肾功能,心电图检查。随访1年。结果:天舒胶囊较氟桂利嗪减少偏头疼发作频率和每月头痛发作持续时间,停药后仍具有阳性结果的持续时间更长(P<0.05)。结论:天舒胶囊较氟桂利嗪减少偏头痛发作频率和严重程度,具有更持久的预防保护作用,副作用小且无锥体外系反应。
AIM： To compare the clinical effect of Tianshu Capsule（ Rhizoma Chuanxiong, Rhizoma Gastrodiae, efc） on migraine with Flunarizine. METHODS： 82 cases of patients with migraine were divided randomly into the treatment group（40 cases）, which were treated with oral Tianshu Capsule, 4 capsules（ 1.36 g）, 3 times daily after meals, and the control group （42 cases ）, which were treated with Flunarizine （Sibelium） 5 mg quaque nocte, for 2 months. One year follow-up was carried out. The frquency and duration of migraine were analyged before and after treatment, and duration of positive results after withdraw of drugs were also recorded. The body weight, blood and urine routine, liver and kidney function as well as electrocardiograph were compared before and after treatment. RESULTS： In the treatment group the frequency and duration of migraine decreased more than that of control group. The positive results remained longer in the Tianshu Capsule group（ P 〈0.05 ）. No responses of extrapyramidal system were found in the treatment group. CONCLUSION： Tianshu Capsule could ameliorate the migraine frequency and duration as well as the severity than that of Flunarizine, and had longer prevention effect on migraine without extrapyramidal system responses.
出处
《中成药》
CAS
CSCD
北大核心
2006年第5期680-682,共3页
Chinese Traditional Patent Medicine
