摘要
目的:探讨体外受精胚胎移植(IVF ET)控制性超排卵(COH)中卵巢反应性与妊娠率的相关性。方法:回顾性分析我所2003年1月至2004年12月期间实施的1030个IVF ET周期,按年龄分为≥35岁组与<35岁组;两组均根据COH获卵数分为反应不良组(获卵数≤4个),反应正常组(获卵数>4个),比较各组间妊娠率。结果:①≥35岁组较<35岁组发生卵巢反应不良的比率明显升高(P<0.001);②≥35岁组中反应正常组和反应不良组临床妊娠率均分别低于相应反应的<35岁组(P<0.01);③同年龄组中卵巢反应不良组与反应正常组妊娠率无显著性差异(P>0.05)。结论:IVF ET中年龄与卵巢反应性相关,是决定妊娠率的重要因素。同年龄阶段只要能获得可移植胚胎,反应不良者妊娠率与反应正常者相比无显著降低。
Objective. To investigate the association of ovarian reactivity and pregnancy rate in in vitro fertilizationembryo transfer （IVF-ET） program. Methods. Women in whom got at least one viable embryo for transfer in IVF-ET was accepted in a prospective analysis contained one thousand and thirty cycles. The women were classified into two groups （≥35y, n = 165 and 〈 35y, n = 865） according to the age of the female partner. Both groups were reclassified into poor responder group （who got less than 4 oocytes） and normal responder group （who got more than 4 oocytes） according to the COH response respectively. Pregnancy rate was compared between each group. Results：There are mere poor responders in women age older than 35y （ ≥35y group） than women younger than 35y （ 〈 35y group） （ P 〈 0. 001）. The pregnancy rate was significantly lower in ≥ 35y group when compared with 〈 35y group,both in poor responders and normal responders （ P〈 0.01）. In the same age group,the pregnancy rate was similar in poor responders and normal responders （ P 〉 0. 05）. Conclusions： The pregnancy rate was mainly determined by age. In the same age group, there is no direct relationship of ovarian reactivity and pregnancy rate when at least one viable embryo can be obtained.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2006年第5期292-294,共3页
Journal of Practical Obstetrics and Gynecology
关键词
体外受精
胚胎移植
卵巢反应
妊娠率
In vitro fertilization
Embryo transfer
Ovarian response
Pregnant rate
