摘要
目的探讨在实验性糖尿病大鼠体内联用18α-甘草酸二铵(DG)和格列本脲(Gli)时,DG对Gli药动学的影响。方法采用RP-HPLC测定实验性糖尿病大鼠单用Gli及与DG联用后Gli的血药浓度。用DAS软件进行药动学分析,比较两组Gli药动学参数的变化。结果DG与Gli联用后,Gli的Ke值较单用时明显减少(P＜0.01),而ρ_(max),AUC_(0-∞)和t_(1/2(Ke))则显著增加(P＜0.01)。其余各药动参数差异无显著性。结论DG可抑制Gli的代谢,使其进入血循环总量增加,消除延缓,但不影响Gli的吸收。提示两药联用时应注意调整剂量,避免不良反应发生。
OBJECTTVE To study the effect of 18α-diammonii glycyrrhizinatis（DG） on phannacokinetics of glibenclamide（Gli） in experimental diabetic rats. METHODS The Gli concentration in rat plasma was determined by RP-HPLC after administrations of Gli and DG ＋ Gli. The phannacokinetics of Gli was analyzed by DAS software and the main pharmacokinetic parameters were compared in the two groups. RESULTS In the rats treated with DG ＋ Gli, the phannacokinetic parameters Ke of glibenclamide was decreased while ρmax, AUC0-∞ and t1/2Ke were increased significantly, compared with Gli-treated group. There was no significant difference between other parameters. CONCLUSION DG may inhibit the metabolism of Gli. So the total amount of Gli in circulation increases and the elimination process is prolonged. But DG has no influence on the absorption of Gli. The dosage of administration may be paid more attention to avoiding adverse reactions.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2006年第10期774-776,共3页
Chinese Pharmaceutical Journal
