摘要
目的探讨3DSPGR磁化传递成像(MTI)在鉴别脑脓肿与坏死囊变性胶质瘤和脑转移瘤的应用价值。方法7例经手术病理(3例)或临床随访(4例)证实的脑脓肿、9例经手术病理证实的坏死囊变性胶质瘤和8例经临床证实的坏死囊变性转移瘤在治疗前接受了常规MR和3DSPGR序列MTI检查,测量并计算病灶囊性区、实性区、同层面对侧正常脑白质区和脑脊液的平均磁化传递率(magnetization transfer ratio,MTR)。结果病灶囊性区、实性区、同层面对侧正常脑白质区和脑脊液的MTR分别依次为(0.0803±0.04)、(0.2259±0.03)、(0.3475±0.02)、(-0.1546±0.15);病灶囊性区与脑脊液的MTR之间存在显著性差异,t=8.911,P<0.001,病灶实性区与正常脑白质区的MTR之间存在显著性差异(t=-20.208,P<0.001);脑脓肿与坏死囊变性胶质瘤和脑转移瘤囊性区的MTR均存在显著性差异(F=37.390,P<0.001),其中脑脓肿与胶质瘤存以及脑脓肿与脑转移瘤有显著性差异(P<0.001),胶质瘤和脑转移瘤无明显差异(P=0.179);实性区域的MTR三者之间无差异。结论3DSPGR-MTI以及MTR的测量在鉴别脑脓肿与坏死囊变性胶质瘤和脑转移瘤有重要价值,可作为常规MRI序列的重要补充。
Objective To study the value of 3DSPGR magnetization transfer imaging （MTI） in differentiating brain abscess from necrotic or cystic glioma and metastasis. Methods Conventional MR imaging and MTI of 3DSPGR sequence were performed in seven patients with brain abscess （3 pathologically verified and 4 clinical following-up confirmed）, nine patients with necrotic or cystic glioma （confirmed by histopathology）, and eight patients with necrotic or cystic metastasis （clinically confirmed） before operations or treatments. Mean magnetization transfer ratio （MTR） cystic and solid parts in abscesses, glioma and metastasis, contralateral normal white matters and cerebrospinal fluid were measured. Results MTRs of cystic and solid parts in all lesions, contralateral normal white matters and cerebrospinal fluid were （0. 0803±0.04）, （0. 2259± 0.03）, （0. 3475±0.02）, （-0. 1546±0.15） respectively. The MTR showed significant differences between cystic parts of all lesions and cerebrospinal fluid （t = 8. 911, P〈0. 001） and between solid parts in all lesions and contralateral normal white matters （t =- 20. 208, P〈0. 001）. The differences of MTR among cystic area of abscesses, glioma and metastasis was significant （F=37. 390, P〈0. 001）. There was significant difference between abscesses and necrotic or cystic areas of gliomas or metastases （abscess ＆ glioma： P〈0. 001, and abscess ＆ metastasis： P〈0. 001）, but not between necrotic or cystic areas of gliomas and metastases （P = 0. 179）. The difference of MTR among solid parts of abscesses, glioma and metastasis was not significant. Conclusion The measurement of MTR could play an important role in differentiating brain abscess from necrotic or cystic glioma and metastasis and was an important supplementary tool for routine MRI.
出处
《中国医学影像技术》
CSCD
北大核心
2006年第5期682-685,共4页
Chinese Journal of Medical Imaging Technology
关键词
磁化传递
磁共振成像
脑脓肿
胶质瘤
肿瘤转移
Magnetization transfer
Magnetic resonance imaging
Brain ahscess
Glioma
Neoplasm metastasis
