摘要
脑电图(EEG)、脑地形图(CTM)能客观地评定大脑的机能活动,凡是作用于大脑的麻醉药均可通过EEG及CTM功率的变化进行比较。本试验45例ASA Ⅰ～Ⅱ级的脑科患者,随机分成三组。在静脉氟芬合剂的先导下,分别给予等效剂量的异丙酚(Ⅰ组)、硫喷妥钠(Ⅱ组)、羟丁酸钠(Ⅲ组),用SW系列智能脑电监测仪持续描记脑电变化。结果三组用药后EEG均首先产生β高频兴奋活动,最大效应期,Ⅰ组无δ波出现,CTM最大功率无明显变化;Ⅱ组有不规律δ波,CTM最大功率明显增加(P<0.05),而Ⅲ组以高幅的2～5 c/s大δ波为主,呈深睡眠型,CTM最大功率增加非常显著(P<0.01),表明异丙酚对中枢系统抑制明显轻于硫喷妥钠、羟丁酸钠,而羟丁酸钠中枢抑制最强。
Cerebral topographic map (CTM) and electroencephalogram (EEG) can evaluate the functional activity of brain, and the purpose of this study was to objectively compare the effect of intravenous anesthetics on brain. Forty-five patients, ASA grade Ⅰ-Ⅱ, undergoing neurosurgery,were randomly divided into three groups after administration of Innovar 2 ml, and then equivalent effective dose of propofol(2～2.5 mg/kg)(Ⅰ),sodium thiopental (4～6mg/kg)(Ⅰ) or gama hydroxybutyrate sodium (70～80mg/kg)(Ⅲ) was intravenously given respectively. All patients were monitored continuously during induction. The high frequent excitative activities of β rhythm appeared immediately after each anesthestic was injected. During the most effective period: in group Ⅰ, there were no δ rhythm in EEG and obvious power change on CTM; in group Ⅱ irregular δ rhythm took place in EEG occasionally and great increase in top power on CTM occured, which showed evident elevation compared with group Ⅰ (P<0.05); in group Ⅲ,δ rhythm 2～5 c/s of EEG were dominant and top power on CTM obviously rose,which was significantly higher than in group Ⅰ or group Ⅱ (P<0.01). The hemodynamic parameters in three groups kept statistically stable except for HR's decreasing markedly in group Ⅲ. It is suggested that propofol was less depression on CNS than sodium thiopentol or gama hydroxybutyrate sodium, and gama hydroxybutyrate sodium was the most depressive.
出处
《中华麻醉学杂志》
CSCD
北大核心
1996年第4期147-149,共3页
Chinese Journal of Anesthesiology
关键词
异丙酚
脑地形图
脑电图
硫喷妥钠
羟丁酸钠
Propofol Gama hydroxybutyrate sodium Sodium thiopental Cerebral topographic map Electroencephalogram
