摘要
目的:探讨超声治疗外阴白色病变的机制。方法:采用免疫组织化学与原位杂交技术研究超声辐射兔外阴皮肤后组织中bFGF蛋白和mRNA的变化。结果:辐射后第4天和第7天bFGF蛋白和mRNA较辐射前明显升高(P<0.01),2周时已恢复正常。结论:通过超声的生物学效应可使组织发生可逆性损伤,细胞膜微小破裂增加,细胞膜通透性提高,同时细胞bFGF产生增加,最后bFGF分泌增加,促进局部微血管的形成,改善微血管和神经末梢的营养状况。
Objective：To investigate the therapy mechanism of white lesions of vulva by ultrasound.Method：The immunohistochemistry and hybridization in situ were used to investigate the changes of bFGF protein and mRNA in vulva skin of rabbit after ultrasound irradiation. Result：After irradiation,bFGF protein and mRNA were high on 4 and 7 days （P〈0.01）,resume normal on 14 day.Conclusion：Ultrasound may make reversible trauma on tissue by its biological effect, increase tiny crack and permeability of plasma membrane, enhance production and secretion of bFGF, promote growth of local microvessel, improve nutrition of microvessel and nerve ending.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2006年第5期405-407,i0001,共4页
Chinese Journal of Rehabilitation Medicine
