摘要
目的探讨病毒性脑炎急性期继发性全身性强直-阵挛发作的危险因素。方法资料完整的急性病毒性脑炎患者374例,其中,病例组继发性全身性强直-阵挛发作组72例,对照组(无抽搐发作组)259例,系同期住院患者;病例组和对照组采用统一的调查表,用MicrosoftAccess2002建立数据库,共52个主项内容,部分主项有下属分项;对研究资料先进行单因素分析,然后进行多因素非条件Logistic回归模型分析。结果经分析筛选出大脑皮质损害、多灶性损害、脑电图异常、昏迷、颅内压升高等5个因素为脑炎后继发癫痫间的独立危险因素。结论病毒性脑炎后急性期强直-阵挛发作的发生主要与大脑皮质损害关系密切,昏迷、颅内压升高可促发脑炎后强直-阵挛发作。
Objective To evaluate the risk factors in patients with tonic-clonic seizures during the acute phase of viral encephalitis. Methods We retrospectively studied 374 patients from April 1982 to December 2003,admitted to the Division of Neurology at our hospital diagnosed as acute viral encephalitis. Of these patients,72 had tonic-clonie seizures and 259 patients had not seizures. Based on a standardized questionnaire,a database was made with Microsoft Access 2002. These data included 52 indexes and some subindexes. Nonconditional multivariate stepwise logistic regression was made after univariate analysis. Odds ratio （OR） and 95% confidence interval after adjustment for possible confounding variables were calculated. Results The independ ent risk factors in tonic-clonie seizures during the acute phase of viral encephalitis were cortical involvement （OR = 27.835 ）, multiple lesions （OR= 7.639）, abnormal electroencephalogram （OR = 4.122）, coma （ OR = 2.737） and raised intracranial pressure （OR = 1.548）. Conclusions Cortical involvement was the main predictive risk factor of tonic-clonic seizures during the acute phase of viral encephalitis. Coma and raised intracranial pressure can induce tonic-clonic seizures after viral encephalitis.
出处
《卒中与神经疾病》
2006年第3期149-152,共4页
Stroke and Nervous Diseases
