摘要
目的探讨胶质纤维酸性蛋白(GFAP)在缺血性中风中的临床意义,以指导临床的诊治。方法收集急性脑梗死病人47例,分别测定48小时内、第3天和第5天的血清GFAP含量,然后分析它与病情轻重、临床分型及预后等的关系。结果脑梗死后GFAP的含量升高,升高幅度和变化规律在OCSP各亚型不同;血清GFAP在大梗死组的含量显著高于其他组;GFAP与NIHSS呈正相关,r=0.410;GFAP与病因分型无关;Logist回归分析显示GFAP不是预后的独立预测因素。结论脑梗死后血清GFAP的水平升高,并与病灶大小、病情严重程度等有关,可用于指导临床诊治。
Objective To investigate the significance of glial fibrillary acidic protein （GFAP） in acute ischemic stroke. Methods 47 acute ischemic stroke patients were enrolled within 2 days after onset. The serum specimens were gathered for GFAP determination with ELISA on admission, at the 3^rd and 5^th day of onset. The relationship among the GFAP and clinical classification and state of stroke were investigated. Results The serum level of GFAP was significantly higher in large infarcts and in cortico subcortical infarcts than other subtypes. The level of GFAP was related to NIHSS, r=0. 410. GFAP wasn＇t related with etiology and prognosis. Conclusions Serum level of GFAP increased after ischemic stroke and was related with infarct size and severity of disease. It may direct diagnosis and treatment of stroke in clinical work.
出处
《青岛医药卫生》
2006年第3期161-164,共4页
Qingdao Medical Journal
关键词
缺血性中风
胶质纤维酸性蛋白
Ischemic stroke Glial fibrillary acidic protein
