摘要
目的建立动物模型研究阴道长时间扩张对漏尿点压及尿道解剖的影响。方法18只成年未生产过的雌性SD大鼠随机分为实验组(12只)和对照组(6只),实验组阴道内置水囊扩张4 h模拟难产,4周后,2组均行尿流动力学检查测膀胱最大容量和漏尿点压(LPP)及喷嚏实验,然后处死所有大鼠取膀胱及尿道行组织学检查。结果实验组膀胱最大容量及LPP均较对照组明显降低(P<0.01),喷嚏实验有45.5%的出现压力性尿失禁(SUI),而对照组无1例出现SUI。组织学检查实验组见尿道周围骨骼肌及平滑肌肌层断列、变薄,胶原组织明显增加,对照组无明显改变。结论阴道长时间扩张可导致SUI,是研究SUI形成机制及治疗的理想模型。
Objective To establish an animal model to investigate the effects of prolonged vaginal distension on the leak-point pressure （LPP） and urethral anatomy. Methods Eighteen virgin female rats were randomly divided into control group （6 rats） and experimental group （12 rats）. In the experimental group, the rats were underwent vaginal distension for4 h. The rats in the control group were not received vaginal distension. The greatest bladder volume and LPP were measured, and sneeze test was performed for all rats in two groups 4 weeks after distension. All the rats were killed after the test and the bladder and urethra were harvested for histological study, Results The greatest bladder volume and LPP were significantly decreased than those of control group, Stress urinary incontinence （SUI） was occurred in 45.5% rats of the experiment group, but none in control group, Histological studies showed that the urethral striated and smooth muscle became thin, but the collagenic tissue was increased. There was no change in control group, Conclusion Prolonged vaginal distension can cause SUI and it is a desirable animal model for studying the mechanism and treatment of SUI.
出处
《中国医师杂志》
CAS
2006年第6期744-746,共3页
Journal of Chinese Physician
关键词
扩张术
阴道
尿道
尿瘘
Vagina
Dilatation
Urethra
Urinary fistula
