摘要
目的 探讨隐睾患儿睾丸组织的病理改变及血清性激素改变。方法 利用光镜和电镜对16例隐睾患儿睾丸组织超微结构改变进行观察。采用放射免疫法对18例隐睾患儿手术前后外周静脉血清睾酮（T）、雌二醇（E2）、卵泡刺激素（FSH）进行测定。结果 镜下观察发现2岁内息儿睾丸组织仅有轻微改变，2岁后睾丸组织学变化随年龄增长渐加重。隐睾患儿术前组血清T明显低于正常，而E2、FSH均明显高于正常，睾丸固定术后3～6个月血清T较术前组明显升高，而血清E2、FSH低于术前组，差异均有显著性（P均〈0．05）。结论 2岁内隐睾患儿睾丸组织病理改变轻微，是手术的最佳时机。睾丸固定术后患儿血清性激素水平明显改善，有利于睾丸功能恢复，手术疗效可靠。
Objective To study testicle＇s pathologic change and serum sex hormone levels in children with cryptorchidis. Methods Sixteen children with cryptorchidis were investigated with light microscope and electromieroseope on testis tissue morphology and ultrastructure. And the levels of serum testosterone（T） ,estradiol（E2） ,follicle - stimulating hormoe（FSH） were measured in 18 children with cryptorchi .dism before and after operation by radioimmunoassay（RIA）. Results Testis tissue investigated with mieroseope only had slightly change in children with eryptorchidis before the age of 2 years, while after the age of 2 years,testicle pathologic change gradually aggravated with the age increasing. The serum levels of T in cryptorchlds before operation were lower compared with that of the normal, but E2, FSH were higher in cryptorchidis compared with that of the＇normal. The serum levels of T increased significantly in 3 - 6 months after operation, whereas E2, FSH decreased significantly（P〈 0.05）. Conclusions Before the age of 2 years, testicle＇s pathologic change in children with cryptorchidis is light. It is the best time for operation. Serum sex hormone levels have significantly improved after operation, which benefits the restoring of testicular function. So the curative effect of operation is credible.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第11期664-665,共2页
Journal of Applied Clinical Pediatrics
基金
广西教育厅科研基金项目资助(20020157)
关键词
隐睾
病理改变
性腺激素类
eryptorchism
pathologic change
gonadal hormones
