摘要
肠道菌群在溃疡性结肠炎(UC)的发病机制中起重要作用。益生菌可能通过生物拮抗、加强肠道上皮屏障功能及调节肠道免疫系统功能等机制参与防治UC,对照临床研究已经证实了益生菌对于UC的维持治疗是有益处的。需要进一步仔细评价严格设计的大样本、多中心、双盲、安慰剂对照的临床试验,研究益生菌制剂的配方、剂量、疗程、疗效和安全性等问题。
It has been demonstrated that the intestinal flora plays an important role in the pathogenesis of ulcerative colitis （UC）. Probiotics can probably prevent and treat UC effectively through the mechanism by mainly modulating mucosal immune activity and epithelial barrier function as a biological antagonist, which has already been proven by clinical trials for maintaining UC treatment. Large samples, multi-center, double-blind, randomized, controlled clinical trials are still further needed to study the formula, dosage, duration, effects and safety of the treatment.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2006年第6期449-452,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
结肠炎
溃疡性
腹痛
腹泻
肠道菌群
益生菌制剂
colitis, ulcerative
abdominal pain
diarrhea
intestinal flora
probioties preparation
