摘要
将２０只豚鼠分为对照组和牙周炎组，每组１０只，用丝线缝扎十高糖食料喂养形成牙周炎，用放射免疫测定法（ＲＩＡ）分析牙周炎形成后两组牙龈和牙槽骨中前列腺素Ｅ２（ＰＧＥ２）含量。结果表明牙周炎组和对照组牙龈组织中ＰＧＥ２含量均高于牙槽骨中的含量，对照组牙龈组织中ＰＧＥ２（３９４．９７±１１８．２７ｐｇ／ｍｇ）为牙槽骨中（１８２．９１±３３．２９ｐｇ／ｍｇ）的２．１倍，牙周炎组龈组织中ＰＧＥ２（９４６．５８±１０６．８６ｐｇ／ｍｇ）为牙槽骨中（３１０．３７±４６．５８ｐｇ／ｍｇ）的３倍。牙周炎组牙龈和牙槽骨中ＰＧＥ２含量与对照组相应组织的ＰＧＥ２比均有非常显著性差异，牙周炎组牙龈组织中ＰＧＥ２为对照组的２．４倍，而牙槽骨中的ＰＧＥ２为对照组牙槽骨的１．７倍。提示豚鼠牙周炎时牙龈和牙槽骨中ＰＧＥ２升高，ＰＧＥ２与牙龈炎症和牙槽骨吸收有密切关系。
20 guinea pigs were equally divided into two groups. Periodontitis was formed with silk thread suture and high sugar diet in one group; the other group was used as the control. The prostaglandin E 2 (PGE 2) in gingiva and in alveolar bone was measured with radioimmunoassay(RIA). PGE 2 level in gingiva in both groups was higher than that in alveolar bone. In the control group PGE 2 in gingiva (394.87±118.27) was 2.1 fold as much as that in alveolar bone(182.91±33.29)( P <0.01); while in the group of periodontitis PGE 2 in gingiva (946.58±106.86) was 3 fold as much as that in alveolar bone(310.37±46.58)( P <0.01). PGE 2 in gingiva and in alveolar bone in the group of periodontitis was 2.4 and 1.7 fold respectively as much as that in the control. PGE 2 may play an important role in gingivitis and alveolar bone resorption, and anti PGE 2 agents, such as indomethacin, may be effective in the treatment of periodontitis.
出处
《实用口腔医学杂志》
CSCD
北大核心
1996年第2期99-101,共3页
Journal of Practical Stomatology
基金
国家自然科学基金
关键词
放射免疫法
牙周炎
前列腺素E
Radioimmunoassay
Guinea pig
Periodontium
Periodontitis
Prostaglandins E (Original article on Page 99)
