摘要
以蜂蜡和乙基纤维素为阻滞剂，包裹羟基磷灰石生物陶瓷人工骨（ＰＨＡ）．内载药物氧氟沙星（ＯＦＬＸ），制成氧氟沙里控释人工骨（ＯＦＬＸ－ＰＨＡ）．对ＯＦＬＸ－ＰＨＡ进行了体外释药量实验。探讨ＰＨＡ包裹阻滞剂后，药物ＯＦＬＸ的释放规律，以及影响ＯＦＬＸ－ＰＨＡ释药速率的因素。
Releasing controlled ofloxacin porous hydroxyapatite(OFLX-PHA) was prepared with wax and efhylcellulose as aretardant.porous hydroxylapatite asa carrier.Experiment of drug-releasing in vitro was made.The drug-releasing mechanism and its affecting-factor of OFLX-PHA was investigated.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1996年第3期137-139,共3页
West China Journal of Pharmaceutical Sciences
关键词
羟基磷灰石
陶瓷人工骨
氧氟沙星
体外释药
Porous hydroxylapatite Ofloxacin Wax Ethylcellulose Drug-releasing in vitro
