摘要
目的:比较银杏叶提取物制剂(ginkgobiloboextract,EGB)舒血宁及银杏达莫对老龄大鼠血浆超(过)氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)含量及血液流变学的影响。方法:24只老龄大鼠随机分为4组:对照组、银杏达莫组、舒血宁组和双嘧达莫组,分别给予生理盐水、银杏达莫、舒血宁和双嘧达莫,各组动物分别腹腔注射相应药物,给药容量均2ml·kg-1,每日1次,连续用药7d。另6只正常大鼠作为正常对照。测定血液流变学指标及血浆SOD、MDA、NO的含量。结果:银杏达莫组与对照组相比,血浆SOD显著升高(P<0.05),MDA含量显著降低(P<0.01),全血粘度值(高切)和纤维蛋白原含量明显降低(P<0.05);舒血宁组与对照组相比,血浆SOD显著升高(P<0.05),全血粘度值(高切)、全血粘度值(低切)和纤维蛋白原含量等均明显降低(P<0.05);双嘧达莫组与对照组相比,纤维蛋白原明显降低(P<0.01),红细胞变形指数明显升高(P<0.05),血浆SOD和MDA含量虽有改变,但差异均无统计学意义;各用药组血浆NO含量均降低,但无统计学意义。银杏达莫组与舒血宁组相比,对老年大鼠血液流变学指标及血浆SOD,MDA和NO含量的影响无明显差别(P>0.05)。结论:舒血宁、银杏达莫对老年大鼠血液流变学指标均有改善作用,并升高老年大鼠血浆SOD,降低MDA的含量,提示两药均具有抗衰老,抗氧化,扩张冠脉血管、脑血管,改善脑缺血症状的作用。
AIM： To compare Yinxingdamo injection with Shuxuening injection on hemorheology＇ and plasma levels of supemxide dismutase （SOD）, malondialdehyde （MDA） and nitrogen monoxidum （NO） in aged rats. METHODS： 24 aged rats were randomly divided into 4 groups： control, Yinxingdamo group, Shuxuening group and dipyridamole group. The rats were given NS, Yinxingdamo injection, Shuxuening injection and dipyridamole, respectively. The administration dosages were 2 ml·kg^-1, once everyday for 7 d successively. Another six normal young rats were arrayed into normal control. Hemorheology and plasma levels of SOD, MDA and NO were measured. RESULTS： After intraperitoneal injection of Yinxingdamo for 7 days, the level of SOD in plasma of aged rats increased （ P 〈 0.05） and the level of MDA decreased （P 〈 0.01）, the whole blood viscosity （at high shear rate） and contents of fibrinogen decreased （P 〈 0.05） compared with those of control group. The level of SOD in plasma of aged rats increased obviously （P 〈 0.05）, the whole blood viscosity （at high or lower shear rate） and content of fibrinogen decreased （ P 〈 0.05） in Shuxuening group compared with those in control group.After intraperitoneal injection of dipyridamole injection,content of fibrinogen decreased （ P 〈 0.01） and index of red blood cell deformation increased （ P 〈 0.05 ） compared with those of control group. Plasma NO contents showed a tendency to decrease, but there was no significant statistical difference between either two groups.There was also no obvious difference on hemorheology and levels of SOD, MDA and NO in plasma between Yinxingdamo group and Shuxuening group （ P 〉 0.05）. CONCLUSION： Changes of hemorheology in aged rats can be improved with Yinxingdamo or Shuxuening, the level of SOD increases and the level of MDA decreases. The resuits suggest that the two drugs have effects of anti-aging,antioxidation, dilating coronary vessels and cerebral vessels and improving the symptom of cerebral ischemia,which may be the pharmacological foundation of preventing and treating high-incidence diseases among aged people of these two drugs.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2006年第5期582-585,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
