肾脏移植诱导免疫耐受的基础与临床研究进展

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摘要建立免疫耐受是器官移植临床工作者一直追求的理想境界,它对在不用免疫抑制剂的情况下维持移植器官长期生存具有重要意义。本文就目前肾脏移植诱导免疫耐受的基础与临床研究的进展作一综述。

作者刘忠国温端改

机构地区苏州大学附属第一医院泌尿外科

出处《国际泌尿系统杂志》 2006年第4期452-457,共6页 International Journal of Urology and Nephrology

关键词肾移植免疫耐受

参考文献27

1Kirk AD,Blair PJ,Tadaki DK,et al.The role of CD154 in organ transplant rejection and acceptance.Philos Trans R Soc Lond B Biol Sci,2001,356:691.
2Waldmann H,Graca L,Cobbold S,et al.Regulatory T cells and organ transplantation.Semin Immunol,2004,16:119-126.
3Sykes M,Sachs DH.Mixed chimerism.Philos Trans R Soc Lond B Biol Sci,2001,356:707-726.
4Buhler LH,Spitzer TR,Sykes M,et al.Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease.Transplantation,2002,74:1405.
5Kawai T,Sachs DH,Cosimi AB.Tolerance to vascularized organ allografts in large-animal models.Curr Opin Immunol,1999,11:516-520.
6Wells AD,Li XC,Strom TB,et al.The role of peripheral T-cell deletion in transplantation tolerance.Philos Trans R Soc Lond B Biol Sci,2001,356:617-623.
7Larsen CP,Elwood ET,Alexander DZ,et al.Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.Nature,1996,381:434.
8Kirk AD,Harlan DM,Armstrong NN,et al.CTLA4-Ig and anti -CD40 ligand prevent renal allograft rejection in primates.Proc Natl Acad Sci USA,1997,94:8789.
9Kirk AD,Burkly LC,Batty DS,et al.Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.Nat Med 1999 ;5:686.
10Xu H,Elster E,Batty D,et al.Effects of dose and duration of anti -CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model.Transplant Proc,2001,33:223.

国际泌尿系统杂志

2006年第4期

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