摘要
目的:考察超微粉碎前后咽爽散中靛蓝和甘草酸的溶出行为。方法:以靛蓝和甘草酸溶出量为指标,采用高效液相色谱法分别对超微粉碎前后咽爽散溶出量进行测定。结果:咽爽散超微粉碎后靛蓝和甘草酸的溶出速率和溶出量显著提高(P<0.01)。结论:超微粉碎有助于咽爽散中靛蓝和甘草酸的溶出。
OBJECTIVE To abserve the dissolution rate of indigo and glycyrrhizic acid in Yanshuangsan powder before and after super fine crushing. METHODS HPLC was used to determine the dissolution rate of Yanshuangsan powder before and after super fine crushing with Indigo and glycyrrhizic acid as index. RESULTS The dissolution rate and amount of indigo and glycyrrhizic acid in the powder increased significantly after super fine crushing（P〈0. 01）. CONCLUSION Super fine crushing processing procedure can improve the dissolution of indigo and glycyrrhizic acid in Yanshuangsan powder.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2006年第7期831-833,共3页
Chinese Journal of Hospital Pharmacy
关键词
咽爽散
超微粉碎
靛蓝
甘草酸
溶出量
Yanshuangsan powder
super fine crushing
Indigo
glycyrrhizic acid
dissolution rate
